Main Article Content

Abstract

Reproductive health is an important part of life continuity. Moringa oleifera plant is reported to have benefits on growth and reproduction that have been tested on animals, such as steroid alkaloids, alkaloid-pyricine, pyrrolidine, phenolics, steroid glycosides, saponins and triterpenoids. This study aims to demonstrate the pharmacological activity of Moringa oleifera Lam. extract as an antifertility agent in the male and female reproductive systems. This study assessed the phytochemical compounds and antifertility effects of moringa on reproductive parameters in both men and women. This study was conducted through a literature study based on an online database search by combining Boolean search terms (“AND”, “OR”) in the electronic databases PubMed, ScienceDirect and Google Scholar. There were 15 articles that met the inclusion and exclusion criteria of the study. Several phytochemical compounds such as tannins, alkaloids, phenols, flavonoids, saponins and anthraquinones were reported in extracts of both flowers, stems, seeds and leaves of the moringa plant. The effects of these compounds have the potential to improve sperm quality, increase testosterone production in men, and affect hormone levels and estrus cycles in female reproduction. These findings support the role of Moringa oleifera as an antifertility agent in various reproductive parameters in both men and women.

Keywords

Moringa oleifera Pharmacology Phytochemical Reproductive

Article Details

References

  1. Abbas, M., Lali, M., Issa, R. A., & Al-suhaimat, R. (2023). Reduction of reproductive toxicity in murine sperm model using Moringa peregrina leaves extracts. Journal of Applied Pharmaceutical Science, 13(11), 50–56. https://doi.org/10.7324/JAPS.2023.141064
  2. Agrawal, S. S., Vishal, D., Sumeet, G., & ... (2018). Antifertility Activity of Ethanol Leaf Extract of Moringa oleifera Lam. in Female Wistar Rats. In Indian Journal of …. pdfs.semanticscholar.org. https://pdfs.semanticscholar.org/5cc1/1736b25d94978afd0f442fccd6d8214bc549.pdf
  3. Amiruddin, Herman, S., Balumbi, M., Rahawarat, M., Darlian, L., & Herman, S. (2024). Moringa oleifera extract affects the diameter of the Graafian follicles in female Mus musculus. Majalah Obstetri & Ginekologi (Journal of Obstetrics & Gynecology Science), 32(1). https://doi.org/10.20473/mog.V32I12024.14-21.Highlights
  4. Aprioku, J. S., & Onyenaturuchi, P. O. (2018). Comparative phytochemical analysis of Moringa oleifera (moringaceae) extracts and reproductive effects of the aqueous leaf, seed and bark extracts in rats …. In J. Pharm. Res. wjpr.s3.ap-south-1.amazonaws.com. https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/1524972654.pdf
  5. Armalina, D., Susilaningsih, N., Saraswati, I., & Annisa, E. (2021). Effect of kelor ( Moringa oleifera Lam ) ethanolic leaves extract on uterus of pregnant mice and its teratogenicity. Journal of the Medical Sciences, 53(4), 329–335.
  6. Attah, A. F., Akindele, O. O., Nnamani, P. O., & ... (2022). Moringa oleifera Seed at the Interface of Food and Medicine: Effect of Extracts on Some Reproductive Parameters, Hepatic and Renal Histology. In Frontiers in pharmacology. frontiersin.org. https://doi.org/10.3389/fphar.2022.816498
  7. Dafaalla, M. M., Hasan, A. W., Idris, O. F., Abdoun, S., Modawe, G. A., & Kabbashi, A. S. (2016). EFFECT OF ETHANOL EXTRACT OF MORINGA OLEIFERA LEAVES ON FERTILITY HORMONE AND SPERM QUALITY OF. World Journal of Pharmaceutical Research, 5(1), 1–11.
  8. Dafaalla, M. M., Hassan, A. W., & ... (2016). Effect of ethanol extract of Moringa oleifera leaves on fertility hormone and sperm quality of Male albino rats. In World J …. wjpr.s3.ap-south-1.amazonaws.com. https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/1451546113.pdf
  9. El-Kashef, M. M. (2022a). Evaluation of using Moringa oleifera leaves meal on physiological response, hormonal changes and variance in reproductive activity outcomes on female rabbits. Egyptian Poultry Science Journal. https://journals.ekb.eg/article_249549.html
  10. El-Kashef, M. M. (2022b). EVALUATION OF USING MORINGA OLEIFERA LEAVES MEAL ON PHYSIOLOGICAL RESPONSE , HORMONAL CHANGES AND VARIANCE IN REPRODUCTIVE ACTIVITY OUTCOMES ON. Egyptian Poultry Science Journal, 5623(42).
  11. El-Kashef, M. M. (2022c). Impact of using moringa oleifera leaves meal in growing rabbit diets on productive performance, carcass traits and blood biochemical changes under heat-stress …. Egyptian Journal of Rabbit Science. https://journals.ekb.eg/article_267921.html
  12. El-Khasef, M. M. (2022). EFFECT OF Moringa Oleifera LEAVES ON PHYSIOLOGICAL RESPONSE, HORMONAL CHANGES AND SEMEN QUALITY OF MALE RABBITS UNDER NORTH SINAI CONDITIONS. Egyptian Journal of Rabbit Science, 32(2), 105–119.
  13. Hendarto, H., Wiweko, B., Prof, M. P. H., Santoso, B., & Harzif, A. K. (2019). KONSENSUS PENANGANAN INFERTILITAS.
  14. Laoung-on, J., Saenphet, K., Jaikang, C., & Sudwan, P. (2021). Effect of Moringa oleifera Lam. Leaf Tea on Sexual Behavior and Reproductive Function in Male Rats. Plants 2021, 10, 2019. academia.edu. https://www.academia.edu/download/73849785/pdf.pdf
  15. Munawir, Sunarni, T., & Saptarini, O. (2024). ANTIFERTILITY ACTIVITY AND CHEMICAL CONTENT OF MORINGA OLEIFERA LAM PLANT EXTRACT ON THE REPRODUCTIVE SYSTEM OF MALE AND FEMALE WHITE RATS. Indonesian Journal of Global Health Research, 6(December), 185–196.
  16. Mutwedu, V. B., Nyongesa, A. W., & Ayagirwe, R. B. B. (2025). Moringa oleifera aqueous seed extracts and its efficacy in the management of heat stress: assessment of physiological parameters in female New Zealand. In Discover Animals. Springer. https://doi.org/10.1007/s44338-025-00058-x
  17. Mutwedu, B. V. (2022). Investigation of the Pharmacological Effects of Moringa Oleifera Aqueous Extract on Oxidative Damages and Reproductive Performances Induced by Heat Stress in …. erepository.uonbi.ac.ke. https://erepository.uonbi.ac.ke/handle/11295/161633
  18. Obediah, G. A., & Paago, G. (2018). Effects of ethanolic extract of M. oleifera seeds and leaves on the reproductive system of female albino rats. In SOJ Biochem. researchgate.net. https://www.researchgate.net/profile/Gogo-Obediah/publication/337683203_Effects_of_Ethanolic_Extract_of_M_Oleifera_Seeds_and_Leaves_on_the_Reproductive_System_of_Female_Albino_Rats/links/5de5a22e299bf10bc33a69a4/Effects-of-Ethanolic-Extract-of-M-Oleifera-
  19. Onyewuchi, C. B., Aprioku, J. S., & ... (2018). Evaluation of the effect of ethanol bark extract of Moringa oleifera on reproductive biology of non-pregnant Wistar albino rats. In J. Complem. Altern. Med academia.edu. https://www.academia.edu/download/101812352/MjM5MDFAQHBm.pdf
  20. Osonuga, I. O., Ogunlade, A. A., Olalekan, S. O., & ... (2020). The effect of aqueous leaves extract of moringa oleifera on testosterone and prolactin level in adult male Wistar rats (Rattus norvegicus). In Nigerian Journal of …. researchgate.net. https://www.researchgate.net/profile/Albert-Ogunlade/publication/356192361_THE_EFFECT_OF_AQUEOUS_LEAVES_EXTRACT_OF_MORINGA_OLEIFERA_ON_TESTOSTERONE_AND_PROLACTIN_LEVEL_IN_ADULT_MALE_WISTAR_RATS_RATTUS_NORVEGICUS/links/67733e2ac1b0135465039095/THE-EFFECT-O
  21. Ovie, F. O., Oliver, N. L., Nwanama, E. K., Elem, C. J., Onyewuchi, M. C., & Esomachi, C. N. (2023). Reproductive record on Ethanolic Extract of Moringa Oleifera Seed on the Testes of Adult Wistar Rats. In European Journal of Theoretical and Applied Sciences. pdfs.semanticscholar.org. https://pdfs.semanticscholar.org/22d8/0ade58cd13ed097c1e71548eca1fc6167870.pdf
  22. Su, X., Lu, G., Ye, L., Shi, R., Zhu, M., Yu, X., Li, Z., Jia, X., & Feng, L. (2023). active components , health bene fi ts and. 24353–24384. https://doi.org/10.1039/d3ra03584k
  23. Uchenna, E. F., N, A. L., Steve, A. C., & O, A. C. (2017). Effect of Moringa Oleifera ( horseradish ) Seed on the Reproductive System of Effect of Moringa Oleifera ( horseradish ) Seed on the Reproductive System of Male Wistar Albino Rats. International Journal of Research Studies in Biosciences, February 2022. https://doi.org/10.20431/2349-0365.0509005
  24. Zeng, B., Xi, Q., Luo, J., Wang, P., Yang, L., Chen, T., Sun, J., Xie, M., Li, M., Zhang, H., He, J., Zhang, Y., & ... (2019). The beneficial effects of Moringa oleifera leaf on reproductive performance in mice. Food Science & …, July 2018, 738–746. https://doi.org/10.1002/fsn3.918