Main Article Content

Abstract

Infection is the highest disease in Indonesia caused by bacteria. One of the bacteria that can cause infection is Staphylococcus aureus which is a gram-positive bacterium. Moringa leaves contain antioxidants which are secondary metabolites of catechol tannins, triterpenoid tannins, flavonoids, anthraquinone saponins, alkaloids, and reducing sugars. The purpose of this study was to determine the antibacterial activity of moringa leaf ointment (Moringa oleifera L. ) as an antibacterial for Staphylococcus aureus. This research method uses experimental. The steps that have been carried out include extraction by maceration from the simplicia powder of Moringa leaves (Moringa oleifera L. ) with 96% ethanol then in a water bath until the extract is thick. Moringa leaf ointment (Moringa oleifera L. ) with a concentration of F1 5%, F2 10%, F315% has met the requirements for good physical properties tests including organoleptic test, homogeneity test, pH, adhesion, spreadability and viscosity. The agar medium used was Nutrient Agar (Na) with the Kirby-Bauer method (Disc Diffusion) divided into 5 groups namely base, positive control, negative control, F1, F2, F3. The results of data analysis in this study used SPSS Statistics version 25 which showed a value (p> 0.05) which could be interpreted as data that there was no difference in the inhibition zone affected by Moringa leaf ethanol extract ointment against Staphylococcus aureus bacteria . The best result of the three formulas is F3 15%.

Keywords

Salep Antibakteri Daun Kelor Staphylococcus aureus

Article Details

References

  1. Admi, M., Sitorus, A. A., & Sutriana, A. (2021). The Sensitivity Level Of Gentamicine , Cholramphenicol and Penicillin Inhibiting The Growth Of Pseudomonas Aeruginosa Bacteria Isolate From Aceh Bull Prepunce. 15(1), 1–6.
  2. Djumaati, F., Yamlean, P. V. Y., & Lolo, W. A. (2018). Formulasi Sediaan Salep Ekstrak Etanol Daun Kelor (Moringa oleifera Lamk.) dan Uji Aktivitas Antibakterinya Terhadap Bakteri Staphylococcus aureus. Pharmacon, 7(1), 22–29. https://doi.org/10.35799/pha.7.2018.18799
  3. Kusumawardhani, A. D., Kalsum, U., & Rini, I. S. (2015). Effect of Betel Leaves Extract Oinment (Piper betle Linn.) on the Number of Fibroblast in IIA Degree Burn Wound on Rat (Rattus norvegicus) Wistar Strain. Majalah Kesehatan FKUB, 2(1), 16–28.
  4. Lasut, T. M., Tiwow, G., Tumbel, S., & Karundeng, E. (2019). Uji Stabilitas Fisik Sediaan Salep Ekstrak Etanol Daun Nangka Artocarpus heterophyllus Lamk. Biofarmasetikal Tropis, 2(1), 63–70. https://doi.org/10.55724/jbiofartrop.v2i1.40
  5. Marpaung, P. N. S., Wullur, A. C., & Yamlean, P. V. Y. (2014). Uji Efektivitas Sediaan Salep Ekstrak Daun Miana (Coleus Scutellarioides [L] Benth.) Untuk Pengobatan Luka Yang Terinfeksi Bakteri Staphylococcus Aureus Pada Kelinci (Oryctolagus Cuniculus). Pharmacon, 3(3). https://doi.org/10.35799/pha.3.2014.5360
  6. Parwanto, M. L. E., Senjaya, H., & Edy, H. J. (2013). Formulasi Salep Antibakteri Ekstrak Etanol Daun Tembelekan ( Lantana camara L ). Jurnal Ilmiah Farmasi, 2(03), 104–108.
  7. Perianus, S., Mohamad, A., & Wintari, T. (2019). Uji Sifat Fisik Sediaan Salep Kombinasi Madu Kelulut (Trigona sp.) Dan Minyak Cengkeh (Syzygium Aromaticum L.). Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN, 4(1), 1–6.
  8. Pratimasari, D., Sugihartini, N., & Yuwono, T. (2015). Evaluasi Sifat Fisik Dan Uji Iritasi Sediaan Salep Minyak Atsiri Bunga Cengkeh Dalam Basis Larut Air. Jurnal Ilmiah Farmasi, 11(1), 9–15. https://doi.org/10.20885/jif.vol11.iss1.art2
  9. Rokhmatunisa, D. (2014). Pengaruh Perbandingan Konsentrasi Vaselin Album (Vaselin Putih) Pada Sifat Fisik Salep Ekstrak Maserasi Daun Pare (Momordica folium). Pengaruh Perbandingan Konsentrasi Vaselin Album (Vaselin Putih) Pada Sifat Fisik Salep Ekstrak Maserasi Daun Pare (Momordica Folium), 3–5.
  10. Syarifuddin, A., Kamal, S., Yuliastuti, F., Pradani, M. P. K., & Septianingrum, N. M. A. N. (2019). Ekstraksi dan identifikasi metabolit sekunder dari isolat AL6 serta potensinya sebagai antibakteri terhadap Escherichia coli. Jurnal Bioteknologi & Biosains Indonesia (JBBI), 6(2), 210. https://doi.org/10.29122/jbbi.v6i2.3516
  11. Syarifuddin, A., Sulistyani, N., & Fakultas Farmasi, Universitas Ahmad Dahlan, Yogyakarta, Indonesia. (2019). Karakterisasi fraksi teraktif senyawa antibiotik isolat KP 13 dengan metode densitometri dan klt-semprot. Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan, 4(1), 156–166. https://doi.org/10.36387/jiis.v4i1.263
  12. Zukhri, S., Murni Sari Dewi, K., Hidayati, N., Muhammadiyah Klaten, S., & Muhamamdiyah Klaten, S. (2018). Uji Sifat Fisik dan Antibakteri Salep Ekstrak Daun Katuk (sauropus androgynus (l) merr.). Jurnal Ilmiah Kesehatan (JIK), XI(1), 1–10.