ANALYSIS OF ADVERSE DRUG REACTIONS (ADRs) AND THEIR SEVERITY IN BREAST CANCER PATIENTS TREATED WITH THE DOCETAXEL-DOXORUBICIN REGIMEN AT SULTAN AGUNG ISLAMIC HOSPITAL

Abstract

The use of the docetaxel-doxorubicin regimen in breast cancer treatment has been associated with Adverse Drug Reactions (ADRs). This study aims to analyze the occurrence of ADRs and their severity in breast cancer patients undergoing therapy with the docetaxel-doxorubicin regimen at the hospital. The research design employed a quantitative cross-sectional approach, and purposive sampling was used as the sampling technique. Six primary Adverse Drug Reactions (ADRs) were identified among breast cancer patients undergoing chemotherapy with the docetaxel-doxorubicin regimen: nausea (21,32%), anemia (13,71%), peripheral neuropathy (7,45%), alopecia (23,01%), cardiac disorders (7,11%), and anorexia (9.81%). Breast cancer patients treated with the docetaxel doxorubicin regimen experienced various levels of ADR severity. Of the 591 ADR incidents recorded, the majority (55.6%) were categorized as severity level 1 (mild), with nausea being the most frequently reported side effect. At severity level 2 (moderate), alopecia was predominant, while at severity level 3 (severe), anemia was the most common reaction. There were no ADR incidents reported at severity levels 4 and 5.