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Apr 22, 2020
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Abstract

Cancer treatment can be done with tumor surgery, radiotherapy,
immunotherapy, and chemotherapy. These treatments effectively kill cancer
cells but have side effects and are resistant to patients. Based on this, further
research is needed related to cancer drugs based on herbal plants, one of which
is by using curcumin from Curcuma longa or turmeric in the form of
nanoparticles to increase bioavailability and solubility. Especially silver
nanoparticles with a mixture of curcumin. The aim of this study was to
determine the characterization and screening of candidate activities to be used
as anticancer drugs from curcumin extract and silver nanoparticles (AgNO3)
containing curcumin carried out solubility test, thin layer chromatography
(TLC) analysis, UV-Vis spectrophotometer analysis, and morphological
analysis with XRD. The results obtained in this study were curcumin extract
insoluble in water while silver nanoparticles could dissolve in water. TLC
analysis on chloroform mixture: ethanol Rf = 0,92 and Rf = 0,94; chloroform:
hexane obtained Rf = 0,36; Rf = 0,36: Rf 0,38; Rf = 0,3. While chloroform:
benzene: methanol eluent has no Rf value. UV-Vis spectra obtained a maximum
absorbance of 4,267 at a wavelength of 290 nm. The morphological analysis of
XRD silver nanoparticles containing curcumin was 17,45 nm. In conclusion,
curcumin extract and silver curcumin nanoparticles have the potential as initial
candidates for anticancer drugs.

Keywords

Curcumin Silver nanoparticles

Article Details

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