Main Article Content

Abstract

Tuberculosis (TB) is a communicable disease caused by M. tuberculosis and known as Acid Fast Bacilli (AFB). The purpose of this study was to analyze the correlation between AFB at the end of the intensive phase and continuation phase and to analyze the variables that associated with sputum conversion at the end of continuation phase in pulmonary TB patient’s category I in several primary public health in Surabaya. This was an observational analytic with a retrospective cohort design. Data were collected by medical records of TB patients from January 2017 to December 2019. One hundred twenty-four of TB patients met the inclusion criteria with 69 male and 55 females, and mean of age was 44.09 ± 12.05 years old. The initial AFB was mostly 1+ (41%). There was a significant correlation between AFB at the end of intensive phase and continuation phase (p-value=0.000; r=0.657) by Kendal-Tau test. Age was significantly associated with sputum conversion at the end of continuation phase (p-value=0.022). The conclusion of this study that there was a significant correlation between AFB at the end of intensive phase and continuation phase

Keywords

Pulmonary TB category I Acid Fast Bacilli (AFB) Sputum Conversion

Article Details

References

  1. Adegbite, B. R., Edoa, J. R., Agbo, P. A., Dejon-Agobé, J. C., Essone, P. N., Lotola-Mougeni, F., Ngwese, M. M., Mfoumbi, A., Mevyann, C., Epola, M., Zinsou, J. F., Honkpehedji, Y. J., Agnandji, S. T., Kremsner, P. G., Alabi, A. S., Adegnika, A. A., & Grobusch, M. P. (2020). Epidemiological, mycobacteriological, and clinical characteristics of smoking pulmonary tuberculosis patients, in Lambaréné, Gabon: A cross-sectional study. American Journal of Tropical Medicine and Hygiene, 103(6), 2501–2505. https://doi.org/10.4269/ajtmh.20-0424
  2. Al-Shaer, M. H., Elewa, H., Alkabab, Y., Nazer, L. H., & Heysell, S. K. (2018). Fixed-dose combination associated with faster time to smear conversion compared to separate tablets of anti-tuberculosis drugs in patients with poorly controlled diabetes and pulmonary tuberculosis in Qatar. BMC Infectious Diseases, 18(1), 4–10. https://doi.org/10.1186/s12879-018-3309-0
  3. Ayu, P. D., & Isfandiari, M. A. (2016). Hubungan Tingkat Kepositifan Bta Awal Dengan Kegagalan Pengobatan Oat Kategori 1. Jurnal Berkala Epidemiologi, 4(1), 126–137. https://doi.org/10.20473/jbe.v4i1.126-137
  4. Babalik, A., Kiziltas, S., Arda, H., Oruc, K., Cetintas, G., & Calisir, H. (2012). Factors affecting smear conversion in tuberculosis management. Medicine Science | International Medical Journal, 1(4), 351. https://doi.org/10.5455/medscience.2012.01.8036
  5. Behnaz, F., Mohammadzadeh, M., & Mohammadzade, G. (2015). Five-Year Assessment of Time of Sputum Smears Conversion and Outcome and Risk Factors of Tuberculosis Patients in Central Iran. Tuberculosis Research and Treatment, 2015, 1–7. https://doi.org/10.1155/2015/609083
  6. Day, C. L., Abrahams, D. A., Lerumo, L., Janse van Rensburg, E., Stone, L., O’rie, T., Pienaar, B., de Kock, M., Kaplan, G., Mahomed, H., Dheda, K., & Hanekom, W. A. (2011). Functional Capacity of Mycobacterium tuberculosis
  7. -Specific T Cell Responses in Humans Is Associated with Mycobacterial Load . The Journal of Immunology, 187(5), 2222–2232. https://doi.org/10.4049/jimmunol.1101122
  8. Departement kesehatan RI 2005. (2005). Pharmaceutical care untuk penyakit tuberkulosis. Pharm World Sci, 18(6), 233–235. https://doi.org/10.1037/0033-3204.30.3.524
  9. Feng, J. Y., Huang, S. F., Ting, W. Y., Chen, Y. C., Lin, Y. Y., Huang, R. M., Lin, C. H., Hwang, J. J., Lee, J. J., Yu, M. C., Yu, K. W., Lee, Y. C., & Su, W. J. (2012). Gender differences in treatment outcomes of tuberculosis patients in Taiwan: A prospective observational study. Clinical Microbiology and Infection, 18(9). https://doi.org/10.1111/j.1469-0691.2012.03931.x
  10. Hadifah, Z., Subronto, Y. W., & Ikhsan, M. R. (2019). Faktor Risiko Gagal Konversi BTA pada Pasien Tuberkulosis Paru Fase Intensif di Kota Yogyakarta. Buletin Penelitian Kesehatan, 47(2), 83–88. https://doi.org/10.22435/bpk.v47i2.1002
  11. Jayakody, W., Harries, A. D., Malhotra, S., de Alwis, S., Samaraweera, S., & Pallewatta, N. (2013). Characteristics and outcomes of tuberculosis patients who fail to smear convert at two months in Sri Lanka. Public Health Action, 3(1), 26–30. https://doi.org/10.5588/pha.12.0090
  12. Kemenkes RI. (2019). Profil Kesehatan Indonesia 2018 [Indonesia Health Profile 2018].
  13. Kenangalem, E., Waramori, G., Pontororing, G. J., Sandjaja, Tjitra, E., Maguire, G., Kelly, P. M., Anstey, N. M., & Ralph, A. P. (2013). Tuberculosis Outcomes in Papua, Indonesia: The Relationship with Different Body Mass Index Characteristics between Papuan and Non-Papuan Ethnic Groups. PLoS ONE, 8(9), 1–9. https://doi.org/10.1371/journal.pone.0076077
  14. Nurjana, M. A. (2015). Faktor Risiko Terjadinya Tubercolosis Paru Usia Produktif (15-49 Tahun) di Indonesia. Media Penelitian Dan Pengembangan Kesehatan, 25(3), 163–170.
  15. Pefura-Yone, E. W., Kengne, A. P., & Kuaban, C. (2014). Non-conversion of sputum culture among patients with smear positive pulmonary tuberculosis in Cameroon: A prospective cohort study. BMC Infectious Diseases, 14(1), 2–7. https://doi.org/10.1186/1471-2334-14-138
  16. Putra, O. N., Damayanti, A., Nurrahman, N. W. D., Devi, T., & Aluf, W. (2019). Evaluation of Category I of Anti-tuberculosis Therapy in Intensive Phase Pulmonary TB by Conversion of Acid-Fast Bacilli Sputum. Pharmaceutical Sciences and Research, 6(3), 183–188. https://doi.org/10.7454/psr.v6i3.4483
  17. Setiowati, R., Ayuningtyas, D., Sakit, R., Banten, U., Administrasi, D., Kesehatan, K., Kesehatan, F., & Universitas, M. (2014). Faktor-Faktor Kegagalan Konversi Pasien TB Paru BTA Positif Kategori I pada Akhir Pengobatan Fase Intensif Conversion Failure at The End of DOTS Intensive Phase among. 37(1), 47–52.
  18. Singla, R., Srinath, D., Gupta, S., Visalakshi, P., Khalid, U. K., Singla, N., Gupta, U. A., Bharty, S. K., & Behera, D. (2009). Risk factors for new pulmonary tuberculosis patients failing treatment under the revised national tuberculosis control programme, India. International Journal of Tuberculosis and Lung Disease, 13(4), 521–526.
  19. Tabrani, I. (2008). Irma Tabrani : Konversi Sputum BTA Pada Fase Intensif TB Paru Kategori Antara Kombinasi Dosis Tetap,USU e-Repository.