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Mar 23, 2021
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May 1, 2021
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Abstract

Topical agents indicated for the treatment of acne have the potential to cause irritation or allergic contact dermatitis. This study investigates the irritancy potential of anti-acne cream of bawang dayak (Eleutherine bulbosa (Mill.) Urb.) previously tested for microbiological effectiveness with the lowest concentration of 5% and the highest concentration of 20%. The method used in this study is the human patch test. A total of 20 volunteers were recruited for the patch test study, testing the cream. The result showed that all volunteers did not experience irritation both in the 5% or 20% bawang dayak extract cream formulations. However, the interview results were found that some volunteers experienced a slight itching without any significant skin adverse reactions on the cream application. Therefore, based on these initial findings it can be safely concluded that the cream of bawang dayak does not cause significant skin adverse reaction and good enough for further development for anti-acne cream dosage form.

Keywords

Acne Bawang dayak Cream Patch test

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References

  1. Aktar N., Khan H.M.S., Ashraf S., Mohammad I.S., Ali A. (2014). Skin depigmentation activity of Crocus sativus extract cream. Tropical Journal of Pharmaceutical Research, 13(11),1803-1808.
  2. Ali A., Akhtar N., Mumtaz A.M., Khan M.S., Iqbal F.M., Zaidi S.S. (2013). In vivo skin irritation potential of a cream containing Moringa oleifera leaf extract. African Journal Pharmacy and Pharmacology, 7(6),289-293.
  3. Ardhany S.D., Effendie R.R., Novaryatiin S. (2019). Uji Iritasi Formulasi Sediaan Krim Ekstrak Bawang Dayak (Eleutherine bulbosa (Mill.) Urb) pada Kelinci Albino Putih. Jurnal Surya Medika, 5(1),63-69.
  4. Ardhany S.D., Novaryatiin S. (2019). Antibacterial activity of ethanolic extract Bawang dayak (Eleutherine bulbosa (Mill.) Urb in cream against Propionibacterium acnes. International Journal of Applied Pharmaceutics, 11(Special Issue 5),1-4.
  5. Canavan T.N, Chen E., Elewski B.E. (2016). Optimizing Non-Antibiotic Treatments for Patients with Acne: A Review. Dermatologic Therapy, 6(4),555-78.
  6. Daud N.S., Akbar A.J., Nurhikma E., Karmilah. (2018). Formulation of Snail Slime (Achatina Fulica) Anti-Acne Emulgel using Tween 80-Span 80 as Emulsifying and HPMC as Gelling Agent. Borneo Journal of Pharmacy,1(2),64-67.
  7. Elsaie L.T., Mohsen A.M.E., Ibrahim I.M., Mohey-Eddin M.H., Elsaie M.L. (2016). Effectiveness of topical peppermint oil on symptomatic treatment of chronic pruritus. Clinical, Cosmetic and Investigational Dermatology, 9,333-8.
  8. Farage M.A., Maibach H.I., Andersen K.E., Lachapelle J.M., Kern P., Ryan C., Ely J., Kanti A. (2011). Historical perspective on the use of visual grading scales in evaluating skin irritation and sensitization. Contact Dermatitis, 65(2),65-75.
  9. Freitas Araújo M.G.D., Hilário F., Vilegas W., Santos L.C.D., Brunetti I.L., Sotomayor C.E., Bauab T.M. (2012). Correlation among antioxidant, antimicrobial, hemolytic, and antiproliferative properties of Leiothrix spiralis leaves extract. International Journal of Molecular Science, 13(7),9260-77.
  10. Górniak I., Bartoszewski R., Króliczewski J. (2019). Comprehensive review of antimicrobial activities of plant flavonoids. Phytochemistry Reviews, 18,241-72.
  11. Hassan A., Ullah H., Israr M. (2019). The antioxidant activity and phytochemical analysis of medical plant Veronica biloba. Letters in Applied NanoBioScience, 8(4),732-738.
  12. Horita K., Tanoue C., Yasoshima M., Ohtani T., Matsunaga K. (2014). Study of the usefulness of patch testing and use test to predict the safety of commercial topical drugs. The Journal of Dermatol, 41(6),505-513.
  13. Khan H., Akhtar N., Ali A. (2014). Effects of Cream Containing Ficus carica L. Fruit Extract on Skin Parameters: In vivo Evaluation. Indian Journal of Pharmaceutical Sciences, 76(6),560-564
  14. Kim S., Oh S., Noh H.B., Ji S., Lee S.H., Koo J.M., Choi C.W., Jhun H.P. (2018). In Vitro Antioxidant and Anti- Propionibacterium acnes Activities of Cold Water, Hot Water, and Methanol Extracts, and Their Respective Ethyl Acetate Fractions, from Sanguisorba officinalis L . Roots. Molecules, 23(11),3001.
  15. Kumar P., Paulose R. (2014). Patch Testing in Suspected Allergic Contact Dermatitis to Cosmetics. Dermatology Research and Practice, 2014,695387.
  16. Kumari R, Mishra RC, Yadav JP. (2020). Antioxidant and cytotoxic studies of Acacia nilotica twig extract and their green synthesized silver nanoparticles. Letters in Applied NanoBioScience,9(2),975-985.
  17. Lukelal E., Tesfaye S., Gebrechristos S., Dires K., Zenebe T., Zegeye N., Feleke G., Kassahun A., Shiferaw Y., Mekonnen A. (2019). Phytochemical analysis and evaluation of skin irritation, acute and sub-acute toxicity of Cymbopogon citratus essential oil in mice and rabbits. Toxicolology Reports, 6,1289-1294.
  18. Mahto A. (2017). Acne vulgaris. Medicine,45(6),386-389.
  19. Maisetta G., Batoni G., Caboni P., Esin S., Rinaldi A.C., Zucca P. (2019). Tannin profile, antioxidant properties, and antimicrobial activity of extracts from two Mediterranean species of parasitic plant Cytinus. BMC Complementary and Alternative Medicine, 19,82.
  20. Massoud Y., Reihaneh B. (2020). Chemical composition and antibacterial activity of methanolic extract from Echinops robustus on typical food-borne pathogens. Letters in Applied NanoBioScience,9(1),849-852.
  22. Moldovan M., Lahmar A., Bogdan C., Parauan S., Tomuta I., Crisan M. (2017). Formulation and evaluation of a water-in-oil cream containing herbal active ingredients and ferulic acid. Clujul Medical, 90(2),212-219.
  23. Novaryatiin S., Ardhany SD. (2019). The Antibacterial Activity of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) from Central Kalimantan Against Acne-Causing Bacteria. International Journal of Applied Pharmaceutics, 11(Special Issue 5),22-25.
  24. Novaryatiin S., Ardhany SD. (2020). Potential Anti-acne: Bawang Dayak (Eleutherine bulbosa (Mill.) Urb) from Central Kalimantan-Indonesia. Pharmacognosy Journal, 12(1),52-57.
  25. Oon H.H., Wong S.N., Wee Aw D.C., Cheong W.K., Goh C.L., Tan H.H. (2019). Acne Management Guidelines by the Dermatological Society of Singapore. The Journal of Clinical and Aesthetic Dermatology,12(7),34-50.
  26. Othman L., Sleiman A., Abdel-Massih R.M. (2019). Antimicrobial Activity of Polyphenols and Alkaloids in Middle Eastern Plants. Frontiers in Microbiology, 10,911.
  27. Otuechere C.A., Durugbo E.U., Adesanya O., Omotolani O.F., Osho A. (2019). Essential oil of Alchornea laxiflora (benth): phytochemical, antimicrobial and toxicity evaluations. Letters in Applied NanoBioScience, 8(3),661-665.
  29. Perumal A., Krishna S.B.N., Sershen, Pillay K., Govender P. (2020). Phytochemical composition and biological investigation of Trichilia emetic Vahl. Seed extracts Letters in Applied NanoBioScience, 9(2),1111-1116.
  30. Platsidaki E., Dessinioti C. (2018). Recent advances in understanding Propionibacterium acnes (Cutibacterium acnes) in acne. F1000Research, 7, F1000 Faculty Rev-1953.
  31. Prabhakar P.K., Nath D., Singh S., Mittal A., Baghel D.S. (2020). Formulation and evaluation of polyherbal anti-acne combination by using in-vitro model. Biointerface Research in Applied Chemistry,10(1),4747-4751.
  32. Pratama M.R., Aziz I.R. (2019). Molecular Docking of Bawang Dayak (Eleutherine bulbosa) Secondary Metabolites as Bacterial Cell Wall Synthesis Inhibitor. In: Proceedings of the 1st International Conference on Science and Technology, Makassar, Indonesia. Ghent: EAI.
  33. Purnamawati S., Indrastuti N., Danarti R., Saefudin T. (2017). The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review. Clinical Medicine and Research, 15(3-4),75-87.
  34. Putri A.N., Laila N., Forestryana D. (2019). Formula Optimization of Annona muricata Folium Ethanolic Extract of Anti Acne Gel Formulation using Factorial Design Method. Borneo Journal of Pharmacy, 2(2),63-70.
  35. Rathi S.K. (2011). Acne vulgaris treatment: the current scenario. Indian Journal of Dermatology, 56(1),7-13.
  36. Satria D., Siahaan M.A. (2017). Formulasi Krim Anti – Aging dari Buah Mangga Manalagi. Jurnal Farmanesia, 4(1),12-30
  37. Saviuc C., Ciubucă B., Dincă G., Bleotu C., Drumea V., Chifiriuc M.C., Popa M., Pircalabioru G.G., Marutescu L., Lazar V. (2017). Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds. International Journal of Molecular Science,18(1),175.
  38. Lazar V. (2017). Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds. International Journal of Molecular Science,18(1),175.
  39. Sutriningsih, Sagal Z., Marhamah. (2018). Formulasi dan Uji Iritasi Gel Antibakteri dari Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi Linn) terhadap Bakteri Staphylococcus aureus dan Pseudomonas aeruginosa. FaST Jurnal Sains Teknologi, 2(1),1-9
  40. Tagousop C.N., Tamokou J.D., Kengne I.C., Ngnokam D., Voutquenne-Nazabadioko L. (2018). Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes. Chemistry Central Journal, 12,97.
  41. Tan A.U., Schlosser B.J., Paller A.S. (2018). A review of diagnosis and treatment of acne in adult female patients. International Journal of Women’s Dermatology, 4(2),56-71.
  42. Wattanakrai P, Suwanachote S, Kulkollakarn S, Rajatanavin N. (2007). The study of human skin irritation of a novel herbal skin care product and ingredients by human single closed patch testing. Journal of the Medical Association of Thailand, 90(6),1116-1122.
  43. Yazdani E., Talebi M., Zarshenas M.M., Moein M. (2019). Evaluation of possible antioxidant activities of barberry solid formulation, a selected formulation from Traditional Persian Medicine (TPM) via various procedures. Biointerface Research in Applied Chemistry, 9(6),4517-4521.
  45. Zuuren E.J.V., Fedorowicz Z., Christensen R., Lavrijsen A., Arents B.W.M. (2017). Emollients and moisturisers for eczema. Cochrane Database Systematic Reviews, 2(2), CD012119.