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Jul 17, 2021
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Dec 1, 2021
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Abstract

Indonesia is a country with fertile soil and rich in plant species. Currently in society the use of medicinal plants as herbal treatment has increased. Elderly people often experience Rheumatoid Arthritis, which is inflammation of the synovial lining of the joints. One of the plants used by the community is red betel leaf (Piper crocatum). However, scientific information related to the potential of red betel as an anti-inflammatory in Rheumatoid Arthritis is still not widely known by the public. This study was conducted to explore the potential of P. crocatum leaves to treat Rheumatoid Arthritis which can be used as references regarding Rheumatoid Arthritis therapy. This study uses a narrative review method from previous studies that were collected related to the topic which was then discussed systematically. By using keywords in the search for Piper crocatum, anti-inflammatory activity, red betel bioactivity, secondary compounds in red betel leaf, and Rheumatoid Arthritis. P. crocatum leaves contain various bioactive compounds. Flavonoids have activity as primary and secondary antioxidants. Flavonoid compounds such as brazilien, brazilin, taxifolin, procyanidin found in red betel have anti-inflammatory activity in rheumatoid arthritis. Brazilin is one of the flavonoid compounds from P. crocatum leaves that has the potential as an anti-inflammatory in rheumatoid arthritis by regulating the transcription factor nuclear factor kappa B (NF-kB) for TNF- expression against inflammation.

Keywords

Antiinflammation Brazilin Flavonoid Piper crocatum Rheumatoid Arthritis

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References

  1. Alam, B., Akter, F., Parvin, N., Sharmin Pia, R., Akter, S., Chowdhury, J., Sifath-E-Jahan, K., and Haque, E. (2012). Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper betle leaves. Avicenna Journal of Phytomedicine Received, Accepted(2), 112.
  2. Alfarabi, M., Bintang, M., Suryani, and Safithri, M. (2010). The Comparative Ability of Antioxidant Activity of Piper crocatum in Inhibiting Fatty Acid Oxidation and Free Radical Scavenging. HAYATI Journal of Biosciences, 17(4), 201–204.
  3. Amarawati, G. A. K., Susanti, N. M. P., and Laksmiani, N. P. L. (2019). Aktivitas Anti-Rheumatoid Arthritis Dari Brazilin Dan Brazilein Secara in Silico. Jurnal Kimia, 13(2), 153–158. https://doi.org/10.24843/jchem.2019.v13.i02.p05
  4. Deligiannidou, G. E., Gougoula, V., Bezirtzoglou, E., Kontogiorgis, C., and Constantinides, T. K. (2021). The role of natural products in rheumatoid arthritis: Current knowledge of basic in vitro and in vivo research. Antioxidants, 10(4), 1–32. https://doi.org/10.3390/antiox10040599
  5. Esti, R. D. D. (2016). Uji Aktivitas Antiinflamasi Topikal Ekstrak Metanol Daun Sirih Merah (Piper crocatum Ruiz & Pav.) Pada Mencit Diinduksi Karagenin. Universitas Sanata Dharma.
  6. Fadlilah, M. (2015). Benefit of Red Betel ( Piper Crocatum Ruiz & Pav .) As Antibiotics. Journal Majority, 4(3), 5.
  7. Fitriyani, A., Winarti, L., Muslichah, S., and Nuri. (2011). Uji Antiinflamasi Ekstrak Metanol Daun Sirih Merah (Piper crocatum Ruiz & Pav) pada Tikus Putih. Majalah Obat Tradisional, 16(1), 34–42.
  8. Ginting, C. N., Lister, I. N. E., Girsang, E., Widowati, W., Yusepany, D. T., Azizah, A. M., and Kusuma, H. S. W. (2021). Hepatotoxicity prevention in Acetaminophen-induced HepG2 cells by red betel (Piper crocatum Ruiz and Pav) extract from Indonesia via antioxidant, anti-inflammatory, and anti-necrotic. Heliyon, 7(1), e05620. https://doi.org/10.1016/j.heliyon.2020.e05620
  9. Harismi, A. (2020). Manfaat Sirih Merah yang Tak Banyak Diketahui Orang. SehatQ.Com. https://www.sehatq.com/artikel/manfaat-sirih-merah-yang-tak-banyak-diketahui-orang (Accessed : 25 March 2021)
  10. Hariyanto, R. A. B. (2017). Penentuan Kandungan Fenolik, Flavonoid dan Aktivitas Antioksidan Ekstrak Propolis Trigona sp. Institut Teknologi Sepuluh November.
  11. Januarti, I. B., Wijayanti, R., Wahyuningsih, S., and Nisa, Z. (2019). Potensi Ekstrak Terpurifikasi Daun Sirih Merah (Piper crocatum Ruiz &Pav) Sebagai Antioksidan Dan Antibakteri. Journal of Pharmaceutical Science and Clinical Research, 4(2), 60–68. https://doi.org/10.20961/jpscr.v4i2.27206
  12. Jouad, H., Lacaille-Dubois, M. A., Lyoussi, B., and Eddouks, M. (2001). Effects of The Flavonoids Extracted from Spergularia purpurea Pers. on Arterial Blood Pressure and Renal Function in Normal and Hypertensive Rats. Journal of Ethnopharmacology, 72(2), 159–163.
  13. Juliantina, F. (2009). Manfaat Sirih Merah (Piper crocatum) Sebagai Agen Anti Bakterial Terhadap Bakteri Gram Positif dan Gram Negatif. Jurnal Kedokteran Dan Kesehatan Indonesia, 1(1), 1-10.
  14. Jung, E. G., Han, K. Il, Hwang, S. G., Kwon, H. J., Patnaik, B. B., Kim, Y. H., and Han, M. D. (2015). Brazilin isolated from caesalpinia sappan L. inhibits rheumatoid arthritis activity in a type-II collagen induced arthritis mouse model. BMC Complementary and Alternative Medicine, 15(1), 1–11. https://doi.org/10.1186/s12906-015-0648-x
  15. Lister, I. N. E., Ginting, C. N., Girsang, E., Nataya, E. D., Azizah, A. M., and Widowati, W. (2020). Hepatoprotective properties of red betel (Piper crocatum Ruiz and Pav) leaves extract towards H2O2-induced HepG2 cells via anti-inflammatory, antinecrotic, antioxidant potency. Saudi Pharmaceutical Journal, 28(10), 1182–1189. https://doi.org/10.1016/j.jsps.2020.08.007
  16. Listiana, D., Effendi, E., and Indriati, B. (2019). Efektivitas Air Rebusan Daun Sirih Merah terhadap Penurunan Kadar Gula Darah pada Pasien Diabetes Melitus di Wilayah Kerja Puskesmas Saling 2018. Jurnal Keperawatan Muhammadiyah Bengkulu, 7(2), 62–70. https://doi.org/10.36085/jkmu.v7i2.418
  17. Maslikah, S. I., Amalia, A., and Afifah, S. (2019). Red betel apigenin compound (Piper crocatum Ruiz Pav.) as an anti-inflammatory rheumatoid arthritis agent through virtual screening. AIP Conference Proceedings, 080003. https://doi.org/10.1063/1.5115741
  18. Maslikah, S. I., Lestari, S. R., Wulandari, N., and No, J. S. (2012). Sirih Merah sebagai Agen Anti-Inflamasi pada Mencit Model Rheumatoid Arthritis. MS Open, 5, 122–131.
  19. Misfa, O., Yuniarti, R., and Prajoko, Y. W. (2020). Effectiveness of Spirulina platensis Extract on Wound Area and TNF-a Levels on Blood: Experimental Studies In Wistar Rats Made Artificially by Vulnus Scissum and Infected by Staphylococcus aureus. Indonesian Journal of Environmental Management and Sustainability, 4(2). https://doi.org/10.26554/ijems.2020.4.2.55-58
  20. Novilia, L., Harahap, U., and Hasibuan, P. A. Z. (2018). Evaluation Of Hepatoprotective Effect Of Ethanolic Extract From Red Betel (Piper Crocatum Ruiz And Pav.) Leaves. Asian Journal of Pharmaceutical and Clinical Research, 11(7), 248. https://doi.org/10.22159/ajpcr.2018.v11i7.25542
  21. Parfati, N., and Windono, T. (2016). Red betel (Piper crocatum Ruiz & Pav) literature review. Media Pharmaceutica Indonesiana, 1(2), 106–115.
  22. Pratiwi, S. U. T., and Hertiani, T. (2017). Efficacy of Massoia Oil in Combination With Some Indonesian Medicinal Plants Oils As Anti-Biofilm Agent Towards Candida Albicans. International Journal of Pharmaceutical Sciences and Research, 8(5), 2013–2025. https://doi.org/10.13040/IJPSR.0975-8232.8(5).2013-25
  23. Puspita, P. J. (2018). Antibacterial Activities of Sirih Merah (Piper crocatum) Leaf Extracts. Journal Curr.Biochem, 5(3), 1–10.
  24. Putri, A. K. (2019). Study of Morphology of Piper betle L. and Its Use in Daily Life. https://doi.org/10.31219/osf.io/94yvq
  25. Reveny, J. (2011). Daya Antimikroba Ekstrak dan Fraksi Daun Sirih Merah ( Piper betle Linn .) Antimicrobial Activity of the Extract and Fraction of Red Betel Leaf ( Piper betle Linn .). Jurnal Ilmu Dasar, 12(1), 6–12.
  26. Rosa, D., S, T., W, T., R, W., and Fichry, M. (2020). Inovasi Handsanitizer Alami Dari Ekstrak Daun Sirih Merah (Piper crocatum) Guna Mencegah Penyebaran COVID-19 Di Desa Ngrundul. Journal of Chemical Information and Modeling, 53(9), 1689–1699.
  27. Rukmini, A., Utomo, D. H., and Laily, A. N. (2020). Family Piperaceae Phytochemical Screening. Jurnal Biologi Dan Pembelajarannya (JB&P), 7(1), 28–32. https://doi.org/10.29407/jbp.v7i1.14805
  28. Serlahwaty, D., Sugiastuti, S., and Ningrum, R. C. (2011). Aktivitas Antioksidan Ekstrak Air dan Etanol 70% Daun Sirih Hijau (Piper betle L.) dan Sirih Merah (Piper cf.fragile Benth.) Dengan Metode Perendaman Radikal Bebas DPPH (pp. 143–146).
  29. Setiawan, A. A., Megawati, S., and Nisa, D. (2016). Uji Aktivitas Esktrak Etanol Daun Sirih Merah(Piper crocatum Ruiz and Pav) Sebagai Antiinflamasi Pada Tikus Putih Jantan Galur Sprague-dawley. Farmagazine, III(1), 1–6. https://media.neliti.com/media/publications/328904-uji-aktivitas-ekstrak-etanol-daun-sirih-df3deb1a.pdf
  30. Singh, J. A., Furst, D. E., Bharat, A., Curtis, J. R., Kavanaugh, A. F., Kremer, J. M., Moreland, L. W., O’Dell, J., Winthrop, K. L., Beukelman, T., Bridges, S. L., Chatham, W. W., Paulus, H. E., Suarez-almazor, M., Bombardier, C., Dougados, M., Khanna, D., King, C. M., Leong, A. L., Saag, K. G. (2012). 2012 Update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care & Research, 64(5), 625–639. https://doi.org/10.1002/acr.21641
  31. Sucita, R. E., Hamid, I. S., Fikri, F., and Purnama, M. T. E. (2019). Ekstrak Etanol Kayu Secang (Caesalpinia sappan L.) Secara Topikal Efektif pada Kepadatan Kolagen Masa Penyembuhan Luka Insisi Tikus Putih. Jurnal Medik Veteriner, 2(2), 119–126. https://doi.org/10.20473/jmv.vol2.iss2.2019.119-126
  32. Wijaya, A. (2020). Uji Antibakteri Ekstrak Etanol Herba Calincing (Oxalis corniculata L) Terhadap Escherichia Coli dan Staphylococcus Auresus. JIKI Jurnal Ilmiah Kesehatan IQRA, 8, 19–24. https://stikesmu-sidrap.e-journal.id/JIKI/article/view/170
  33. Wilmana, P., and Gan, S. (2012). Analgesik-Antiparetik. In Analgesik Anti- Inflamasi Nonsteroid, dan Obat gangguan Sendi Lainnya. FKUI Press.
  34. Zuhroh, F. (2018). Uji Efek Antiinflamasi Ekstrak Etanol Daun Sirih (Piper betle L.) Dan Pengaruhnya Terhadap Jumlah Leukosit Pada Tikus Jantan Yang Diinduksi Karagenan. Universitas Sumatera Utara.
  35. Zuraidah. (2015). Pengujian Ekstrak Daun Sirih (Piper Sp.) Yang Digunakan Oleh Para Wanita Di Gampong Dayah Bubue, Pidie Dalam Mengatasi Kandidiasis Akibat Cendawan Candida Albican. Internasional Journal of Child and Gender Studies, 1(2), 109–118.