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Aug 24, 2021
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Abstract

End-Stage Renal Disease (ESRD) is a condition of severe renal damage associated with a higher incidence of hypertension that requires antihypertensive therapy to prevent the worsening disease. Therefore, patients who received more than two types of antihypertensives have affected medication adherence. This study aimed to analyze relationship between the number of antihypertensives and medication adherence in ESRD patients. The study was a cross-sectional design involving 77 participants selected by a purposive sampling technique at Outpatient Private Hospital Buleleng Bali in July-September 2020. Data were collected based on patient’s medical records and the Probabilistic Medication Adherence Scale (ProMAS) questionnaire. The inclusion criteria were ESRD patients aged ≥18 years, with hypertension history, taking the same antihypertensive for three months before the study, sign informed consent, and completed medical record data. Those who were a weak general condition and cognitive impairment were excluded from the study. Data were analyzed using a Kruskal-Wallis test. The results showed that overall, of patients were <65 years old (80.52%), male (70.13%), duration of ESRD <5 years (89.61%), primarily high school (57.14%), and without complications (57.1%). Most patients used a combination of two antihypertensives (35.07%), and 61.04% has a high medication adherence. There was no significant relationship between the number of antihypertensives and medication adherence (p=0.847). Nevertheless, it was still shown that the higher number of antihypertensives in ESRD patients was directly proportional to the lower medication adherence.

Keywords

End-stage renal disease Antihypertensive Medication adherence

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References

  1. Algabbani, F. M., & Algabbani, A. M. (2020). Treatment Adherence Among Patients with Hypertension: Findings from A Cross-Sectional Study. Clinical Hypertension, 26(1), 18.
  2. Alikari, V., Maria, T., Vasiliki, M., Fotoula, B., Kalliopi, P., Evangelos, F., & Sofia, Z. (2018). Adherence to Therapeutic Regimen in Adults Patients Undergoing Hemodialysis: The Role of Demographic and Clinical Characteristics. International Archives of Nursing and Health Care, 4(3).
  3. Alkatheri, A. M., Alyousif, S. M., Alshabanah, N., & Abdulkareem, M. (2014). of Kidney Diseases and Transplantation Original Article Medication Adherence among Adult Patients on Hemodialysis. Saudi Journal of Kidney Diseases and Transplantation, 25(4), 762–768.
  4. Bakris, G.L., Burkart, J., Weinhandl, E. (2016). Intensive Hemodialysis, Blood Pressure, And Antihypertensive Medication Use. Am J Kidney Dis. 9.
  5. Becker, G. J., Wheeler, D. C., De Zeeuw, D., Fujita, T., Furth, S. L., Holdaas, H., Mendis, S., Oparil, S., Perkovic, V., Saad Rodrigues, C. I., Sarnak, M. J., Schernthaner, G., Tomson, C. R. V., & Zoccali, C. (2012). Kidney disease: Improving global outcomes (KDIGO) blood pressure work group. KDIGO clinical practice guideline for the management of blood pressure in chronic kidney disease. Kidney International Supplements, 2(5), 337–414.
  6. Bucharles, S. G. E., Wallbach, K. K. S., Moraes, T. P. de, & Pecoits-Filho, R. (2019). Hypertension in patients on dialysis: Diagnosis, mechanisms, and management. Brazilian Journal of Nephrology, 41(3), 400–411
  7. Buffet, L., & Ricchetti, C. (2012). Chronic Kidney Disease and Hypertension: A Destructive Combination. US Pharm, 37(6), 26–29.
  8. Burnier, M., Polychronopoulou, E., & Wuerzner, G. (2020). Hypertension and Drug Adherence in the Elderly. Frontiers in Cardiovascular Medicine, 7, 49.
  9. Burns, M.A., Schwinghammer, T. L., Wells, B. G., Malone, P. M., & Kolesar, J. (2016). Pharmacotherapy: Principles & Practice: Fourth Edition. (4th ed.). Mc Graw Hill Education.
  10. Chang, T. I., & Winkelmayer, W. C. (2010). Kidney Disease and Antihypertensive Medication Adherence: The Need for Improved Measurement Tools. American Journal of Kidney Diseases, 56(3), 423–426.
  11. Damayanti, P. H. (2020). Identifikasi Kepatuhan Penggunaan Obat dan Kejadian Penyakit Ginjal Kronis pada Pasien Hipertensi di Puskesmas Gamping Ii. Skripsi. Universitas Islam Indonesia, 68.
  12. Dani, R., Utami, G. T., & Bayhakki. (2015). Hubungan Motivasi, Harapan, dan Dukungan Petugas Kesehatan Terhadap Kepatuhan Pasien Gagal Ginjal Kronik Untuk Menjalani Hemodialisis. JOM, 2(2), 10.
  13. Dawood, A., Khalil, M., & Ibrahim, N. (2018). Effect Of Self-Care Interventions On Adherence Of Geriatric Patients Undergoing Hemodialysis With The Therapeutic Regimen. The Malaysian Journal of Nursing 9(4).
  14. Farida, L. S., Thaha, M., & Susanti, D. (2018). Characteristics of Patients with End-Stage Renal Disease at Dialysis Unit Dr. Soetomo General Hospital Surabaya. Biomolecular and Health Science Journal, 1(2), 97.
  15. Faselis, C., Doumas, M., & Papademetriou, V. (2011). Common Secondary Causes of Resistant Hypertension and Rational for Treatment. International Journal of Hypertension, 2011, 1–17.
  16. Fitriani., Nugroho, A., Inayati., 2011. Evaluasi Penggunaan Terapi Antihipertensi Terhadap Tekanan Darah Pradialisis pada Pasien Rawat Jalan dengan End Stage Renal Disease (ESRD) yang Menjalani Hemodialisis Rutin Di RS PKU Muhammadiyah Yogyakarta. Jurnal Manajemen dan Pelayanan Farmasi 1(3).
  17. Gast, A., & Mathes, T. (2019). Medication Adherence Influencing Factors—An (Updated) Overview of Systematic Reviews. Systematic Reviews, 8(1), 112.
  18. Ghimire, S., Peterson, G. M., Castelino, R. L., Jose, M. D., & Zaidi, S. T. R. (2016). Medication Regimen Complexity and Adherence in Haemodialysis Patients: An Exploratory Study. American Journal of Nephrology, 43(5), 318–324.
  19. Goldberg, I., & Krause, I. (2016). The Role of Gender In Chronic Kidney Disease. European Medical Journal, 1(2), 7.
  20. Gunaseelan, R., Surudarma, I. W., Wihandani, D. M., & Sutadarma, I. W. G. (2020). Prevalence of anemia on chronic kidney disease and its influenced factors in Sanglah General Hospital 2015-2017, Bali. Intisari Sains Medis, 11(1), 248.
  21. Hernandez, E. (2015). A Review of the JNC 8 Blood Pressure Guideline. Texas Heart Institute Journal, 42(3), 226–228
  22. Husada, I., (2019). Hubungan Faktor Demografi Terhadap Tingkat Depresi Pada Pasien Hemodialisa Di RSUD Wates Kulonprogo. Skripsi. Universitas Aisyiyah Yogyakarta
  23. Imelda, F., Susalit, E., Marbun, M. B. M., & Rumende, C. M. (2017). Gambaran Klinis dan Kualitas Hidup Pasien Penyakit Ginjal Tahap Akhir yang Menjalani Hemodialisis Dua Kali Dibandingkan Tiga Kali Seminggu. Jurnal Penyakit Dalam Indonesia, 4(3), 128.
  24. IRR. (2018). 11th Report of Indonesian Renal Registry 2018. Report of Indonesian Renal Registry, 1–46. https://www.indonesianrenalregistry.org/data/IRR 2018.pdf
  25. Kamaliah, N. I., Cahaya, N., & Rahmah, S. (2021). Gambaran Karakteristik Pasien Gagal Ginjal Kronik Yang Menggunakan Suplemen Kalsium di Poliklinik Sub Spesialis Ginjal Hipertensi Rawat Jalan RSUD Ulin Banjarmasin. Jurnal Pharmascience, 8(1), 111.
  26. Kefale, B., Tadesse, Y., & Alebachew, M. (2019). Retracted: Management Practice, and Adherence and Its Contributing Factors among Patients with Chronic Kidney Disease at Tikur Anbessa Specialized Hospital: A Hospital Based Cross-Sectional Study. International Journal of Nephrology, 2019, 1–1.
  27. Kim, S. J., Kwon, O. D., Cho, B., Oh, S.-W., Lee, C. M., & Choi, H.-C. (2019). Effects of combination drugs on antihypertensive medication adherence in a real-world setting: A Korean Nationwide Study. BMJ Open, 9(6), e029862.
  28. Kleppe, M., Lacroix, J., Ham, J., & Midden, C. (2015). The development of the ProMAS: A Probabilistic Medication Adherence Scale. Patient Preference and Adherence, 355.
  29. Ku, E., Lee, B. J., Wei, J., & Weir, M. R. (2019). Hypertension in CKD: Core Curriculum 2019. American Journal of Kidney Diseases, 74(1), 120–131.
  30. Kusniawati, K. (2018). Hubungan Kepatuhan Menjalani Hemodialisis Dan Dukungan Keluarga Dengan Kualitas Hidup Pasien Gagal Ginjal Kronik Di Ruang Hemodialisa Rumah Sakit Umum Kabupaten Tangerang. Jurnal Medikes (Media Informasi Kesehatan), 5(2), 206–233.
  31. Kusyariadi. (2016). Perawatan Daya Ingat Lansia Menggunakan Slow-Stroke Back Massage di Unit Pelaksana Teknis Panti Sosial Lanjut Usia Kabupaten Jember. NurseLine Journal, 1(1), 100–112
  32. Lam, W. Y., & Fresco, P. (2015). Medication Adherence Measures: An Overview. BioMed Research International, 2015, 1–12.
  33. Lee, W.-C., Lee, Y.-T., Li, L.-C., Ng, H.-Y., Kuo, W.-H., Lin, P.-T., Liao, Y.-C., Chiou, T., & Lee, C.-T. (2018). The Number of Comorbidities Predicts Renal Outcomes in Patients with Stage 3–5 Chronic Kidney Disease. Journal of Clinical Medicine, 7(12), 493.
  34. Mahato, S. K. S., Apidechkul, T., Sriwongpan, P., Hada, R., Sharma, G. N., Nayak, S. K., & Mahato, R. K. (2020). Factors Associated with Quality Of Life Among Chronic Kidney Disease Patients In Nepal: A Cross-Sectional Study. Health and Quality of Life Outcomes, 18(1), 207.
  35. Mahmoodi, H., Nahand, F. J., Shaghaghi, A., Shooshtari, S., Asghari, M., Jafarabadi, & Allahverdipour, H. (2019). Gender based cognitive determinants of medication adherence in older adults with chronic conditions. Patient Preference and Adherence, 13, 1733–1744.
  36. Makusidi, A., Chijioke, A., Rafiu, M., & Okoro, E. (2011). Factors Influencing Level Of Blood Pressure Control In Chronic Kidney Disease Patients From Ilorin, Nigeria. Sahel Medical Journal, 14(2), 12.
  37. Mancia, G., Rea, F., Corrao, G., & Grassi, G. (2019). Two-Drug Combinations as First-Step Antihypertensive Treatment. Circulation Research, 124(7), 1113–1123.
  38. Naalweh, K., Barakat, M., Sweileh, M., Aljabi, S. (2017). Treatment Adherence and Perception in Patients On Maintenance Hemodialysis: A Cross – Sectional Study From Palestine. BMC Nephrology 18:178
  39. Narváez, K. G., & Vidales, M. (2019). The Patient with Hypertension and New Guidelines for Therapy: Current Opinion in Anaesthesiology, 32(3), 421–426.
  40. Nauval, M., & Hasanah, U. (2019). Hubungan Antara Jenis Terapi Hipertensi Pada Angka Kejadian Gagal Ginjal Di RSUD Dr. R. Soedjono Selong. Jurnal Kedokteran, 4(1), 679.
  41. NKF. (2010). About Chronic Kidney Disease: A Guide for Patients and Their Families. In New York: National Kidney Foundation, Inc., p.8.
  42. Nielsen, T. M., Frøjk Juhl, M., Feldt-Rasmussen, B., & Thomsen, T. (2018). Adherence to medication in patients with chronic kidney disease: A systematic review of qualitative research. Clinical Kidney Journal, 11(4), 513–527.
  43. Nitta, K., Okada, K., Yanai, M., & Takahashi, S. (2013). Aging and Chronic Kidney Disease. Kidney and Blood Pressure Research, 38(1), 109–120.
  44. Okoro, R. N., Ummate, I., Ohieku, J. D., Yakubu, S. I., Adibe, M. O., & Okonta, M. J. (2020). Evaluation of medication adherence and predictors of sub-optimal adherence among pre-dialysis patients with chronic kidney disease. Medicine Access @ Point of Care, 4.
  45. Ozen, N., Cinar, F. I., Askin, D., Dilek, M. U. T., & Turker, T. (2019). Nonadherence in hemodialysis patients and related factors: A multicenter study. Journal of Nursing Research, 27(4), 1–11.
  46. Pameswari, P., Halim, A., & Yustika, L. (2016). Tingkat Kepatuhan Penggunaan Obat pada Pasien Tuberkulosis di Rumah Sakit Mayjen H. A Thalib Kabupaten Kerinci. Jurnal Sains Farmasi & Klinis, 2(2), 116.
  47. Parker, K., Bull-Engelstad, I., Aasebø, W., von der Lippe, N., Reier-Nilsen, M., Os, I., & Stavem, K. (2019). Medication regimen complexity and medication adherence in elderly patients with chronic kidney disease. Hemodialysis International, 23(3), 333–342.
  48. Polańska, B., Uchmanowicz, I., Wysocka, A., Uchmanowicz, B., Lomper, K., & Fal, A. M. (2017). Factors affecting the quality of life of chronic dialysis patients. European Journal of Public Health, 27(2), 262–267.
  49. Priyadi, A., Mandalas, E., & Juriah. (2016). Evaluasi Penggunaan Obat Antihipertensi pada Pasien Gagal Ginjal Kronik di Salah Satu Rumah Sakit Swasta di Kota Bandung. Prosiding Rakernas dan Pertemuan Ilmiah Tahunan IAI.
  50. Pugh, D., Gallacher, P. J., & Dhaun, N. (2019). Management of Hypertension in Chronic Kidney Disease. Drugs, 79(4), 365–379.
  51. Putri, L. S. A., Satriyasa, B. K., & Jawi, I. M. (2019). Gambaran Pola Penggunaan Obat Antihipertensi Pada Pasien Hipertensi Di Instalasi Rawat Inap RSUP Sanglah Denpasar Tahun 2016. Jurnal Medika Udayana, 8, 8.
  52. Rai, P., Rai, P., Bhat, R., & Bedi, S. (2019). Chronic Kidney Disease among Middle-Aged and Elderly Population: A cross-sectional screening in a Hospital Camp in Varanasi, India. Saudi Journal of Kidney Diseases and Transplantation, 30(4), 795.
  53. Rakshitha B., G. K., N., G. N., S., P., D., Nagaral, J. V., N., M., & C. R., D. (2019). Adherence to treatment in patients undergoing dialysis. International Journal of Basic & Clinical Pharmacology, 8(5), 1024.
  54. Riskesdas, K. (2018). Hasil Utama Riset Kesehata Dasar (RISKESDAS). Journal of Physics A: Mathematical and Theoretical, 44(8), 1–200.
  55. Roever, L., & Palandri Chagas, A. C. (2017). Editorial: Cardiac Remodeling: New Insights in Physiological and Pathological Adaptations. Frontiers in Physiology, 8, 751.
  56. Rossignol, P., Massy, Z. A., Azizi, M., Bakris, G., Ritz, E., Covic, A., Goldsmith, D., Heine, G. H. (2015). The double challenge of resistant hypertension and chronic kidney disease. The Lancet, 386(10003), 1588–1598.
  57. Roy, L., White-Guay, B., Dorais, M., Dragomir, A., Lessard, M. dan Perreault, S., 2013. Adherence to antihypertensive agents improves risk reduction of end-stage renal disease. Kidney International 84, 570–577.
  58. Salwa A. (2013). Evaluasi Penggunaan Obat Antihipertensi Pada Pasien Hipertensi dengan Gagal Ginjal di Instalasi Rawat Inap RS “X”, Skripsi. Surakarta: Universitas Muhammadiyah Surakarta.
  59. Saran, R., Robinson, B., Abbott, K. C., Bragg-Gresham, J., Chen, X., Gipson, D., Gu, H., Hirth, R. A., Hutton, D., Jin, Y., Kapke, A. (2020). US Renal Data System 2019 Annual Data Report: Epidemiology of Kidney Disease in the United States. American Journal of Kidney Diseases, 75(1), A6–A7.
  60. Schmitt, K. E., Edie, C. F., Laflam, P., Simbartl, L. A., & Thakar, C. V. (2010). Adherence to Antihypertensive Agents and Blood Pressure Control in Chronic Kidney Disease. American Journal of Nephrology, 32(6), 541–548.
  61. Sekti, B. H., & Aprilianti, R. G. (2019). Hubungan Pola Pengobatan Gagal Ginjal Kronik Terhadap Kepatuhan Pada Pasien Gagal Ginjal Kronik Di Instalasi Hemodialisa Rumah Sakit “X” Malang. Jurnal Kesehatan Hesti Wira Sakti, 7(2), 10.
  62. Shina, S. (2020). Monotherapy versus combination therapy for the initial treatment of hypertension. Journal of Clinical and Preventive Cardiology, 9(2), 78.
  63. Sitiaga, S. (2015). Hubungan Tingkat Pendidikan, Pengetahuan Dan Dukungan Keluarga Dengan Asupan Protein Pasien Gagal Ginjal Kronik (GGK) Yang Menjalani Hemodialisa (HD) Rawat Jalan Di RSUD Kabupaten Sukoharjo. Universitas Muhammadiyah Surakarta.
  64. Sontakke, K., Budania, R., Bajait, C., Jaiswal, K., & Pimpalkhute, S. (2015). Evaluation of adherence to therapy in patients of chronic kidney disease. Indian Journal of Pharmacology, 47(6), 668–671.
  65. Supadmi, W. (2011). Evaluasi Penggunaan Obat Anti Hipertensi Pada Pasien Gagal Ginjal Kronik Yang Menjalani Hemodialisis Evaluation of Drug Use in Anti Hypertension Patients Who Chronic Renal Failure Undergo Hemodialysis. Jurnal Ilmiah Kefarmasian, 1(1), 67–80.
  66. Syamsiah, N. (2011). Fakultas Ilmu Keperawatan Program Studi Magister Keperawatan Kekhususan Keperawatan Medikal Bedah Universitas Indonesia Depok, Juli 201. Skripsi. Kekhususan Keperawatan Medikal Bedah Universitas Indonesia 142.
  67. Tangkiatkumjai, M., Walker, D.-M., Praditpornsilpa, K., & Boardman, H. (2017). Association between medication adherence and clinical outcomes in patients with chronic kidney disease: A prospective cohort study. Clinical and Experimental Nephrology, 21(3), 504–512.
  68. Tesfaye, W. H., McKercher, C., Peterson, G. M., Castelino, R. L., Jose, M., Zaidi, S. T. R., & Wimmer, B. C. (2020). Medication Adherence, Burden and Health-Related Quality of Life in Adults with Predialysis Chronic Kidney Disease: A Prospective Cohort Study. International Journal of Environmental Research and Public Health, 17(1), 371.
  69. Tung, Y.-C., Huang, Y.-C., Wu, L.-S., Chang, C.-J., & Chu, P.-H. (2017). Medication compliance and clinical outcomes of fixed-dose combinations vs free combinations of an angiotensin II receptor blocker and a calcium channel blocker in hypertension treatment. The Journal of Clinical Hypertension, 19(10), 983–989
  70. Unger, T., Borghi, C., Charchar, F., Khan, N. A., Poulter, N. R., Prabhakaran, D., Ramirez, A., Schlaich, M., Stergiou, G. S., Tomaszewski, M., Wainford, R. D., Williams, B., & Schutte, A. E. (2020). 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension, 45, 24.
  71. Wakai, E., Ikemura, K., Kato, C., & Okuda, M. (2021). Effect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension. PLoS ONE, 16(6 June), 1–10.
  72. Wati, M. R., Mustofa, & Puspitasari, I. (2015). Pengaruh konseling apoteker komunitas terhadap pasien hipertensi. JMPF, 5(1), 14–21.
  73. Widayati, D., & Lestari, N. (2017). Peningkatan Kualitas Hidup Pada Penderita Gagal Ginjal Kronik Yang Menjalani Terapi Hemodialisa Melalui Psychological Intervention Di Unit Hemodialisa Rsud Gambiran Kediri. Jurnal Ilmu Kesehatan, 3(2), 6.
  74. Yap, A. F., Thirumoorthy, T., & Kwan, Y. H. (2016). Medication adherence in the elderly. Journal of Clinical Gerontology and Geriatrics, 7(2), 64–67.