Article Sidebar

Submitted
Oct 29, 2021
Published
Feb 25, 2022
Download
Pdf
Statistic
Read Counter : 577 Download : 995

Downloads

Download data is not yet available.

Main Article Content

Abstract

Diabetes Mellitus is a metabolic disease characterized by hyperglycemia due to defects in insulin secretion, insulin action, or both. This study aimed to determine the antihyperglycemic activity of ethanol extract of teak (Tectona grandis L.) leaves in streptozotocin-induced rats. A total of 24 rats were grouped into 6 groups, normal control (Kn), positive control (K+), negative control (K-), and the three groups of teak leaf ethanol extract doses of 100, 200, and 300 mg/kg BW (K1, K2, respectively). and K3), mice were treated for 7 days. Before being given treatment, the rats were first induced using streptozotocin at a dose of 40 mg/kg BW. The results showed the administration of ethanol extract of teak (Tectona grandis L) leaves. doses of 100, 200, and 300 mg/kg BW with the positive control (K+) had significant antihyperglycemic activity in male Wistar strain rats based on the Oneway ANOVA test and post hoc LSD test.

Keywords

Diabetes mellitus Tectona grandis L Blood sugar levels

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

References

  1. Ajie, R. B. (2015). White dragon fruit (Hylocereus undatus) potential as diabetes mellitus treatment. Jurnal Majority, 4(1)
  2. Anani, S., Udiyono, A., & Ginanjar, P. (2012). Hubungan Antara Perilaku Pengendalian Diabetes dan Kadar Glukosa Darah Pasien Rawat Jalan Diabetes Melitus. Jurnal Kesehatan Masyarakat, 1(2), 466–478. Retrieved from http://ejournals1.undip.ac.id/index.php/jkm
  3. Arifin, B., & Ibrahim, S. (2018). Struktur, Bioaktivitas Dan Antioksidan Flavonoid. Jurnal Zarah, 6(1), 21–29. https://doi.org/10.31629/zarah.v6i1.313
  4. Courtney, A. (2012). formularies. In Pocket Handbook of Nonhuman Primate Clinical Medicine (pp. 213–218). CRC Press. https://doi.org/10.1201/b12934-13
  5. Eliza, I., Tatontos, E. Y., Rohmi, R., & Jiwintarum, Y. (2018). Tea Bag Biji Alpukat (Persea Americana Mill) terhadap Kadar Gula Darah Tikus Putih (Rattus Norvegicus). Quality: Jurnal Kesehatan, 11(2), 56–62. https://doi.org/10.36082/qjk.v11i2.66
  6. Fajriaty, I., I H, H., & Setyaningrum, R. (2018). Skrining Fitokimia Lapis Titpis Dari Ekstrak Etanol Daun Bintangur (Calophyllum soulattri Burm. F.). Jurnal Pendidikan Informatika Dan Sains, 7(1), 54–67.
  7. Kementrian Kesehatan Republik Indonesia. (2020). tetap produktif, cegah dan atasi diabetes mellitus. Pusat Data Dan Informasi Kementrian Kesehatan RI.
  8. Kumalasari, E., Susanto, Y., Rahmi, M. Y., & Febrianty, R. D. (2019). Pengaruh Pemberian Ekstrak Etanol Daun Ramania (Bouea macrophylla Griffith) Terhadap Penurunan Kadar Gula Darah Mencit Putih (Mus muscullus) Yang Diinduksi Aloksan. Journal Current Pharmaceutical Sciences, 2(2), 2598–2095.
  9. Lestari, I. C. (2018). Efek Antidiabetik Ekstrak Etanol Daun Mahkota Dewa (Phaleria macrocarpa) Pada Tikus Diabetes Yang Diinduksi Streptozotosin. Biomedika, 10(2). https://doi.org/10.23917/biomedika.v10i2.7019
  10. Nayeem, N., & Karvekar, M. D. (2012). Effect of plant stages on analgesic and antiinflammatory activity of the leaves of Tectona grandis. European Journal of Experimental Biology, 2(2), 396–399. Retrieved from file:///C:/Users/asus/Downloads/Effect_of_plant_stages_on_analgesic_and_anti_infla.pdf
  11. Rosyadi, I., & Hariono, B. (2018). Potensi Imunologi Serbuk Umbi Tanaman Sarang Semut (Myrmecodia tuberose) Terhadap Tikus Wistar yang Diinduksi Streptozotocin. Jurnal Sain Veteriner, 35(2), 159. https://doi.org/10.22146/jsv.34664
  12. Rosyadi, I., Romadhona, E., Utami, A. T., Hijrati, Y. N., & Santosa, C. M. (2018). Gambaran kadar gula darah tikus wistar diabetes hasil induksi streptozotocin dosis tunggal. ARSHI Veterinary Letters, 2(3), 41–42. https://doi.org/10.29244/avl.2.3.41-42
  13. Sari, I. (2015). Variasi Lama Maserasi Daun Tanaman Jati ( Tectona grandis Linn . F ) dan Pemanfaatannya sebagai Pewarna Alami dalam Sediaan Lipstik. Majalah Farmasi Sains Dan Kesehatan, 1(2), 18–22.
  14. Siahaan, G., Nainggolan, E., & Lestrina, D. (2015). Hubungan Asupan Zat Gizi dengan Trigliserida dan Kadar Glukosa Darah pada Vegetarian. Indonesian Journal of Human Nutrition, 2(1), 48–60. https://doi.org/10.21776/ub.ijhn.2015.002.01.5
  15. Sharma, P. V., & Samanta, K. C. (2011). Hypoglycemic activity of methanolic extract of tectona grandis linn. root in alloxan induced diabetic rats. Journal of Applied Pharmaceutical Science, 1(4), 106–109.
  16. Suryanti, V., Kusumaningsih, T., Marliyana, S. D., Setyono, H. A., & Trisnawati, E. W. (2020). Identification of active compounds and antioxidant activity of teak (Tectona grandis) leaves. Biodiversitas, 21(3), 946–952. https://doi.org/10.13057/biodiv/d210313
  17. Utami, Y. P., Taebe, B., & Fatmawati. (2016). Standardisasi parameter spesifik dan non spesifik ekstrak etanol daun murbei (Morus alba L.) asal Kabupaten Soppeng Provinsi Sulawesi Selatan. Journal of Pharmaceutical and Medicinal Sciences, 1(2), 48–52. Retrieved from https://www.jpms-stifa.com/index.php/jpms/article/view/21/18
  18. Widiyastuti, L., & Putranti, W. (2019). Penetapan Parameter Non Spesifik Dan Spesifik Ekstrak Daun Salam (Syzgium polyanthum). Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi Dan Kesehatan, 4(1), 107–116. https://doi.org/10.36387/jiis.v4i1.232
  19. Vyas, P., Yadav, D. K., & Khandelwal, P. (2019, August 18). Tectona grandis (teak)–A review on its phytochemical and therapeutic potential. Natural Product Research. Taylor and Francis Ltd. https://doi.org/10.1080/14786419.2018.1440217