Article Sidebar

Submitted
Jul 19, 2022
Published
May 15, 2023
Download
Pdf
Statistic
Read Counter : 597 Download : 531

Downloads

Download data is not yet available.

Main Article Content

Abstract

Traditional medicine, which is generally considered safer than modern medicine, makes people choose alternative treatments using medicinal plants, one of which is to treat pain. One of the medicinal plants used to treat pain is a plant that contains flavonoids, one of which is the Sungkai plant (Penorema canescens Jack). The research design used was The Static Group Comparison, where the test animals used were divided into 5 groups, each group consisting of 5 mice. Group 1 was given 1 percent of CMC. Group II was given ethanol extract of Sungkai leaves at a dose of 300 mg/Kg BW. Group III was given EEDS at a dose of 600 mg/kg BW. Group IV was given EEDS at a dose of 900 mg/Kg BW. Group V was given paracetamol suspension. The results showed that there was an analgesic activity in the EEDS group, dose I was 50 percentage, dose II was 55,798 percentage, and dose III was 69,564 percentage. The study concluded that statisti-cally there was no significant difference in analgesic activity in white male mice between the EEDS doses I, II, and III groups and the paracetamol group.

Keywords

Extract Sungkai Leaf Analgesic

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

References

  1. Afrianti, R., Yenti, R., & Meustika, D. (2015). Analgesic Activity Test of Papaya Leaf Ethanol Extract (Carica papaya L.) in Male White Mice Induced by 1% Acetic Acid. Journal of Pharmaceutical & Clinical Sciences, 1(1), 54. https://doi.org/10.29208/jsfk.2014.1.1.12
  2. Arifin, H., Alwi, T. I., Aisyahharma, O., & Juwita, D. A. (2018). Study of Analgesic Effects and Subacute Toxicity of Ethanol Extract of Kitolod Leaves (Isotoma longiflora L.) in Male White Mice. Journal of Pharmaceutical & Clinical Sciencess, 5(2), Article 2. https://doi.org/10.25077/jsfk.5.2.112-118.2018
  3. Auliah, N., Lotuconsina, A. A., & Thalib, M. (2019). Analgesic Effect Test of Jackfruit Leaf Ethanol Extract (Artocarpus heterophyllus Lam.) Against Acetic Acid Induced Mice (Mus Musculus). Indonesian Pharmaceutical Research Journal, 1(2), Article 2. https://doi.org/10.33759/jrki.v1i2.24
  4. Brata, A., & Wasih, E.A. (2021). Test the antipyretic effect of Sungkai leaf infusion (Peronema canescens) on male white mice (Mus musculus). Health Information Research, 10:164–173. Health Information Research, 10:164–173.
  5. Depkes, R. I. (1993). Phytochemical Testing and Development Guidelines: Pharmacological Screening, Phytochemical Testing, and Clinical Testing. Foundation for the Development of Natural Material Drugs, Jakarta.
  6. Galani, V.J, & Patel, B.G. (2011). Analgesic and Anti-inflammatory Activity of Argyreia speciosa and Sphearanthus indicus in the Experimental Animals. Global Journal of Pharmacology, 5: 54–59. Global Journal of Pharmacology, 5: 54–59, 5: 54-59.
  7. Goyal, M., Tewatia, N., Vashisht, H., Jain, R., & Kumar, S. (2021). Novel coronavirus (COVID-19); Global efforts and effective investigational medicines: A review. Journal of Infection and Public Health, 14: 910–921.
  8. Harniawati, D, & Widya, T. Y. (2014). Tocap (Toga Education Program) through Improving Educative Teaching About Implementing Healthy Living in Elementary Schools in Kediri. Proceeding Biology Education Conference: Biology, Science, Enviromental, and Learning, 11(1), 1084–1087.
  9. Henny. (2010). Analgetic Tests of Sambiloto Leaf Ethanolic Extract (Andrographis paniculata Nees) In Swiss Female Mice Using Chemical Stimulation Method.
  10. Inayati, A. (2010). Test the Analgesic and Anti-Inflammatory Effects of Ethanol Extract 70. Pharmacy, J., Medicine, F., and Health, I.,
  11. Islamudin, A. (2018). Analgesic Effect Test of African Leaf Ethanol Extract (Vernonia amygdalina Del) on White Mice (Mus musculus L) with the Witkin Method. Scientific papers. University of Indonesia.
  12. Kartikawati, E, & Deswati, D. A. (2021). Testing the Analgetic Effect of Ethanol Extract of Java Acid Leaves (Tamarindus indica L) on Switzerland Male Mice. Journal of Sabdariffarma, 9: 11–18.
  13. Latief, M. (2021). Antidiabetic Activity of Sungkai (Peronema canescens Jack) Leaves Ethanol Extract on the Male Mice Induced Alloxan Monohydrate.
  14. Lumintang, R. F., Wuisan, J., & Wowor, P. M. (2015). Analgesic Effect Test of Matoa (Pometia pinnata) Bark Extract in Mice (Mus musculus). EBiomedik, 3(2), Article 2. https://doi.org/10.35790/ebm.v3i2.8620
  15. Melisa, E., Muhaimin, Yuliawati, & K, F. S. (2022). Acute Toxicity Test of Sungkai Leaf Ethanol Extract (Peronema cenescens Jack) on Kidney Function. Pharmacy and Pharmacology Magazine, 26(April), 32–37. https://doi.org/10.20956/mff.v26i1.19447
  16. Mirzaie, A., Halaji, M., Dehkordi, F. S., Ranjbar, R., & Noorbazargan, H. (2020a). A narrative literature review on traditional medicine options for treatment of corona virus disease 2019 (COVID-19). Complementary Therapies in Clinical Practice, 40, 101214. https://doi.org/10.1016/j.ctcp.2020.101214
  17. Nabila, K. (2021). Nabila, K. (2021). Acute Toxicity Test of Sungkai Leaf Ethanol Extract (Peronema canescens Jack) on the Liver of White Mice (Mus musculus Linn). Jambi University.
  18. Pasita, E. (2018). Analgesic Effect Test of Ethanol Extract of African Leaves (Vernonia amygdalina Del) on White Mice (Mus musculus L) Using the Wikin Method Scientific Paper. Kupang Ministry of Health Polytechnic.
  19. Puspitasari, Hesti, & T. widiyani. (2023). Male white mice (Mus musculus L.) An analgetic activity of sedges (Cyperus rotundus L.) extract on white mal.
  20. Rahman, U. (2021). The Effect of Ethanol Extract of Sungkai Leaves (Peronema canescens Jack) as an anti-inflammatory on the soles of the feet of white rats. Andalas University Faculty of Pharmacy, 1–3.
  21. Riduwan. (2003). Relevance of Aristotle's Virtue Ethics for the Equity Accountant Profession for the Equity Accountant Profession (Journal of Economics and Finance). https://ejournal.stiesia.ac.id/ekuitas/article/view/363
  22. Saifudin, A, Rahayu, V., & Teruna, H.Y. (2011). Textbook of standardization of natural medicinal ingredients. Yogyakarta: Gajah Mada University Press, First edition 50: 1–26.
  23. Santoso, S. (2002). SPSS Versi 11.5 Cetakan Kedua. Jakarta: Gramedia.
  24. Sari, L. O. R. K. (2006). Pemanfaatan Obat Tradisional Dengan Pertimbangan Manfaat Dan Keamanannya. Pharmaceutical Sciences and Research, 3(1), 1–7. https://doi.org/10.7454/psr.v3i1.3394
  25. Sari, R. K. (2021). Identification of the Causes of Citizen Non-Compliance with the Implementation of the 3M Health Protocol during the Covid 19 Pandemic (Case Study of 3M Health Protocol Violators in Ciracas, East Jakarta). Jurnal Akrab Juara, 6(1), Article 1.
  26. Sentat, T., & Pangestu, S. (2016). Analgesic Effect Test of Kersen Leaf Ethanol Extract (Muntingia calabura L.) in Male White Mice (Mus Musculus) With Acetic Acid Pain Induction. Jurnal Ilmiah Manuntung, 2(2), Article 2. https://doi.org/10.51352/jim.v2i2.59