Main Article Content

Abstract

Cinnamon (Cinnamomum burmanii) and VCO (Virgin Coconut Oil) essential oils contain cinnamaldehyde and lauric acid which have potential for hair growth, they can affect the physical stability of hair tonic preparations. This study aims to determine the physical stability and determine the effect of the irritation effect on hair tonic preparations of a combination of cinnamon essential oil and VCO. Cinnamon essential oil hair tonic preparations were made with a concentration of 1% (F1), 3% (F2), and 5% (F3) and then tested for physical characteristics including organoleptic tests, homogeneity, pH, density test, and viscosity. Evaluation of physical stability was carried out using the cycling test method. Data were statistically analyzed using One Way Anova. The results of the irritation test were analyzed descriptively using the primary irritation index obtained from the appearance of erythema and edema on the rabbit's skin. Observation of the physical stability test on organoleptic and homogeneity showed that formula I had a cloudy white color, a characteristic cinnamon aroma, a slightly thick liquid, and was homogeneous; formula 2 and 3 has a clear color, characteristic of cinnamon aroma, slightly viscous and homogeneous liquid; stable pH in formula 2; stable density in formulas 1, 2 and 3; and stable viscosity in formulas 2 and 3. The results of the hair tonic irritation test showed that the primary irritation index for F1, F2, and F3 was 0.0; 0.3; 0.3 and it can be concluded that F2 and F3 can irritate with very mild categories.

Keywords

Cycle test Erythema & edema Irritation index Physical characteristics

Article Details

References

  1. Aini, Q. (2017). Uji Aktivitas Pertumbuhan Rambut Kelinci Jantan Dari Sediaan Hair Tonic Yang Mengandung Ekstrak Etanol Daun Mangkokan (Nothopanax Scutellarium L.). Jurnal Farmasi Lampung, vol. 6, no. 2.
  2. Alamsyah, A.N. (2005). Virgin Coconut Oil Minyak Penakluk Aneka Penyakit. Jakarta: PT. Agro Media
  3. Allen, L.V., Popovich, N.G., & Ansel, H.C. (2011). Ansel, s pharmaceutical dosage forms and drug delivery system, 9th edition, Lippincott, USA, 389-394.
  4. Andersen, H., Gazerani, P., & Arendt-Nielsen, L. (2016). High-concentration L-menthol Exhibits Counter-irritancy to Neurogenic Inflammation, Thermal, and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde, Journal of Pain, 17, 10-12.
  5. Ambari, Y., Fitra, N., Arista, W., Iif, H., & Butet, S. (2020). Studi Formulasi Sediaan Lip Balm Ekstrak Kayu Secang (Caesalpinia sappan L.) dengan Variasi Beeswax. Islamic Pharm, 5(2), 36–45.
  6. Apriani, E.S, Ahmadi, A., & Noviani, V. (2021) Formulation and Evaluation of Water Fraction Hair Tonic Containing Flavonoids from Ethanolic Extract of Green Tea Leaves
  7. (Camellia sinensis L.), Majalah obat tradisional, Vol. 26(2), p 77-83, ISSN-p: 1410-5918 ISSN-e: 2406-9086.
  8. Bajaj, S., Singla, D., & Sakhuja., N. (2012). Stability testing of pharmaceutical products, Journal of applied pharmaceutical applied, 02 (03); 2012:129-138.
  9. BPOM. (2013). Peraturan Kepala Badan Pengawas Obat dan Makanan Republik Indonesia Nomor 34 Tahun 2013 Tentang Kriteria dan tata cara pengajuan notifikasi Kosmetika.Depkes RI.Jakarta.
  10. BPOM. (2014). Pedoman Uji Toksisitas Nonklinik Secara In Vitro. Depkes RI. Jakarta, 66-70.
  11. Harlim, A. (2017). Buku Ajar Ilmu Kesehatan Kulit Dan Kelamin Dasar Diagnosis Dermatologi. FK UKI, Jakarta, 100.
  12. Indriana, L., Wimpie, P & I Gusti, M. (2018). Minyak Atsiri Kayu Manis (Cinnamoum burmanii) Topikal Memiliki Efektivitas Yang Sama Dengan Minoxidil Dalam Menambah Panjang Rambut Dan Ukuran Diameter Folikel Rambut Pada Tikus Putih Jantan Galur Wistar (Rattus norvegicus). Indonesian Journal of Anti Aging Medicine, 2(1), 14–17.
  13. Indriyani, F., & Susi, E. (2021). Formulasi dan Uji Stabilitas Hair Tonic Ekstrak Lidah Buaya (Aloe vera L.) dan Seledri (Apium graviolens L.). Indonesian Journal On Medical Science, 8(1), 19.
  14. Kurniawidjaja, L., Fatma, L., Mila, T & Doni, H. (2021). Konsep Dasar Toksikologi Industri, Fakultas Kesehatan Masyarakat Universitas Indonesia, Depok, 124&164.
  15. Lestari, IS., Darusman, F., & Dewi, L, M. (2020). Formulasi Sediaan Sampo Antiketombe Dari Minyak Atsiri Kulit Batang Kayu Manis (Cinnamomum burmani Nees ex BI.) dan Uji Aktivitas Antijamur Candica albicans Secara In Vitro. Prosiding Farmasi, 6, 61.
  16. Muhammud, A., Amin, A.R., Bakar, R.A., &Jaafar, R. (2014). The Effectiveness of Coconut Oil Mixed with Herbs to Promote Hair Growth. International Journal of Ethics in Engineering & Management Education, 1(3), 27–30. SSN: 2348-4748, Volume 1.
  17. Putra, M.M., Dewantara, I.G.N.A., & Swastini, D. (2014). Pengaruh Lama Penyimpanan Terhadap Nilai pH Sediaan Cold Cream Kombinasi Ekstrak Kulit Buah Manggis (Garcinia mangostana L.), Herba Pegagan (Centella asiatica) dan Daun Gaharu (Gyrinops versteegii (gilg) Domke). Jurnal farmasi Udayana, Vol.3, No1.
  18. Puluh, E.A., Hosea, J.E., & Jainer, P.S. (2019). Formulasi dan Uji Antibakteri Sediaan Masker Gel Peel-Off Ekstrak Etanol Daun Alpukat (Persea americana Mill.) Terhadap Bakteri Staphylococcus epidermidis Sebagai Antijerawat, Pharmacon, 8 (4), 866.
  19. Rahman, A., Ika, Y., & Binar, A. (2013) Formulasi Lotion Ekstrak Rimpang Bangle (Zingiber purpureum Roxb) Dengan Variasi Konsentrasi Trietanolamin Sebagai Emulgator dan Uji Iritasinya. Pharmacy, 10, 52.
  20. Safitri, C & Luluk, J. (2019). Formulasi dan Uji Mutu Fisik Sediaan Lotion Ekstrak Kulit Buah Jagung (Zea mays L.), Jurnal Insan Farmasi Indonesia, 2, 181.
  21. Setiaji & Prayugo, S. (2006), Membuat VCO Berkualitas Tinggi, Jakarta: Penebar Swadaya.
  22. Sikkema, J., Debont, J & Poolman, B., 1994, Interaction of Cyclic Hydrocarbon with Biological Membranes, The Journal of Biological Chemistry, 269 (11), 8024.
  23. Stanojević, L., Stanojević, J., Savić, V., Cvetkovic, D., Kolarevic, A., Marjanović-Balaban, Ž., & Nikolic, L. (2019), Peppermint and Basil Essential Oils: Chemical Composition, in vitro Antioxidant Activity and in vivo Estimation of Skin Irritation. Journal of Essential Oil-Bearing Plants JEOP, 22(4):1-5, DOI-10.1080/0972060X.2019.1661793.
  24. Sugesti, R., Febriana, T.W., & Dwi, S.R. (2018). Karakteristik Hair Tonik Menggunakan Minyak Kayu Putih (Melaleuca sp) Sebagai Bahan Aktif, Program Studi Kehutanan, Universitas Mataram, 3, 8.
  25. Trayes, KP., Studdiford, JS., Pickle, S., & Tully, AS. (2013) Edema: diagnosis and management. Am Fam Physician. PMID: 23939641, 88(2):102-10.
  26. Usman, R.S, & Yuliana. (2019). Pengaruh Penggunaan Buah Alpukat dan Virgin Coconut Oil (VCO) Terhadap Perawatan Rambut Rontok. Jurnal Pendidikan dan keluarga, [S.l.], v. 11, n. 02, p. 74-85, ISSN 2549-9823.
  27. Verdini, L., Budi, S., Tiurma, T., Ahmad, S., & I, W.T.W. (2022), Komponen Bioaktif Ekstrak Akuades Kayu Manis (Cinnamomum burmanii Blume) Asal Sumatera, Indonesia, Jurnal Teknologi dan Industri Hasil Pertanian, 27 (1), 28.
  28. Yang W, Chen X, Li Y, Guo S, Wang Z, & Yu X. Advances in Pharmacological Activities of Terpenoids. Natural Product Communications. 2020;15(3). doi:10.1177/1934578X20903555
  29. Zulfa, E., Liya, L & Mimik, M. (2018). Formulasi Sediaan Krim Daun Binahong (Anredera cordifolia (Ten.) Steenis): Kajian Karakteristik Fisika Kimia Dan Uji Iritasi Kulit. Inovasi Teknik Kimia, 3(1), 51