Article Sidebar

Submitted
Nov 23, 2022
Published
Mar 25, 2023
Download
Pdf
Statistic
Read Counter : 267 Download : 232

Downloads

Download data is not yet available.

Main Article Content

Abstract

Malaria remains a leading cause of death in Papua and combination of Dihydroartemisin -Piperaquine (DHP) and Primaquine (PQ) is recommended treatment to replace chloroquine out since chloroquine resistance present. Moreover, awareness of rational prescription and adherence may be the first priority in malaria treatment in preventing death and resistance in Papua. This study aimed to assess the rationality of antimalaria prescription in the public and private sectors of Papua Province. This cross-sectional study was conducted.  Overall, 571 prescriptions were included in this study and more than half of prescription was rational (65%). This study was predominantly female (65%). More than half was diagnosed by P. falciparum (54%), using referred using the public hospital for treatment (54%) and self-identified as Papuan (50%). According to type of malaria, incorrect of prescription DHP and PQ were 20% and 18%, respectively. The multiple logistic regression model showed that female was significantly associated to receive irrational of prescriptions than males (OR = 1.549; 95% CI =1.004-2.389). Participants who had P. falciparum increased the likelihood of irrational of prescriptions (OR= 1.641; 95% CI =1.144-2.355). There is a need to have a continuum strategy to improve access and utilization of malaria case management in both public and private health facilities. Inequality gender based on prescribers needs to be investigated. Competence improvement among healthcare providers needs to be a priority to prevent antimalarial resistance.

Keywords

Malaria Primaquin Chloroquine resistance Rational prescription Papua Indonesia

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

References

  1. Anosike, C., Chu-Madu, C. N., Igboeli, N. U., Adibe, M. O., & Ukwe, C. V. (2020). The participation of community pharmacists in the case management of malaria in enugu metropolis, nigeria: A cross-sectional survey. Malawi Medical Journal, 32(4), 218–225. https://doi.org/10.4314/mmj.v32i4.7
  2. Baird, J. K., Valecha, N., Duparc, S., White, N. J., & Price, R. N. (2016). Diagnosis and treatment of plasmodium vivax malaria. American Journal of Tropical Medicine and Hygiene, 95(Suppl 6), 35–51. https://doi.org/10.4269/ajtmh.16-0171
  3. Bursac, Z., Gauss, C. H., Williams, D. K., & Hosmer, D. W. (2008). Purposeful selection of variables in logistic regression. Source Code for Biology and Medicine, 3, 1–8. https://doi.org/10.1186/1751-0473-3-17
  4. Chu, C. S., & White, N. J. (2021). The prevention and treatment of Plasmodium vivax malaria. PLoS Medicine, 18(4 April), 1–21. https://doi.org/10.1371/journal.pmed.1003561
  5. Departemen Kesehatan RI. (2009). Buku Saku Penatalaksanaan Kasus Malaria. http://www.pdpersi.co.id/kanalpersi/data/elibrary/bukusaku_malaria.pdf
  6. Ezenduka C.C., O. M. J. . E. C. O. (2014). Adherence to treatment guidelines for uncomplicated malaria at two public health. Journal of Pharmaceutical Policy and Practice, 1–10.
  7. Farooq, U., & Mahajan, R. C. (2004). Drug resistance in malaria. J Vect Borne Dis, 41(September & December), 45–53. https://doi.org/10.1007/978-3-319-48683-3_19
  8. Febrinasari, N., Santoso, A., Rosyid, A., Meilani, A. D., Sultan, U. I., & Rasional, P. O. (2021). Penggunaan obat rasional (POR) berdasarkan indikator pelayanan kefarmasian pada Puskesmas di Semarang. Jurnal Farmasi Sains Dan Praktis, 7(1), 44–51.
  9. Fried, M., & Duffy, P. E. (2017). Malaria during Pregnancy. Cold Spring Harb Perspectives Medicine, 7(6). https://doi.org/10.1101/cshperspect.a025551
  10. Mahittikorn, A., Mala, W., Wilairatana, P., Siri, S., Masangkay, F. R., Kotepui, K. U., & Kotepui, M. (2022). Prevalence, anti-malarial chemoprophylaxis and causes of deaths for severe imported malaria: A systematic review and meta-analysis. Travel Medicine and Infectious Disease, 49(July), 102408. https://doi.org/10.1016/j.tmaid.2022.102408
  11. Ofori-Asenso, R., & Agyeman, A. (2016). Irrational Use of Medicines—A Summary of Key Concepts. Pharmacy, 4(4), 35. https://doi.org/10.3390/pharmacy4040035
  12. Oyinaka, B., Umar, N., Aminu, N., Akinleye, C., & Nuhu, T. (2021). Knowledge and attitude of primary healthcare workers towards rational prescription of Artemisinin-based combination therapy in the treatment of uncomplicated malaria in Ondo State, southwestern Nigeria. Journal of Pre-Clinical and Clinical Research, 15(1), 5–14. https://doi.org/10.26444/jpccr/131762
  13. Parthasarathi, A., Puvvada, R., Patel, H., Bhandari, P., & Nagpal, S. (2021). Evaluation of Medication Errors in a Tertiary Care Hospital of a Low- to Middle-Income Country. Cureus, 13(7). https://doi.org/10.7759/cureus.16769
  14. Risberg, G., Johansson, E. E., & Hamberg, K. (2009). A theoretical model for analysing gender bias in medicine. International Journal for Equity in Health, 8, 1–8. https://doi.org/10.1186/1475-9276-8-28
  15. Sianturi, E. I., Latifah, E., Pane, M., Perwitasari, D. A., Satibi, Kristina, S. A., Hastuti, E. B., Pavlovich, J., & Taxis, K. (2021). Knowledge, empathy, and willingness to counsel patients with HIV among Indonesian pharmacists: a national survey of stigma. AIDS Care, 1–8. https://doi.org/10.1080/09540121.2021.1883506
  16. Sianturi, Elfride I., Perwitasari, D. A., Soltief, S. N., Atiqul Islam, M., Geboers, B., & Taxis, K. (2021). Health literacy of people living with HIV in a rural area in Indonesia: A cross-sectional study. Health and Social Care in the Community, 29(1), 127–134. https://doi.org/10.1111/hsc.13075
  17. Siswantoro, H., Ratcliff, A., Wuwung, M., Marisela, R., Rumaseuw, R., Laihad, F., Ebsworth, P., Ansley, N., Price, R., & E Tjitra. (2006). Efficacy of existing antimalarial drugs for uncomplicated malaria in Timika Papua, Indonesia. Med J Indonesia, 15(4).
  18. Sitohang, V., Sariwati, E., Fajariyani, S. B., Hwang, D., Kurnia, B., Hapsari, R. K., Laihad, F. J., Sumiwi, M. E., Pronyk, P., & Hawley, W. A. (2018). Malaria elimination in Indonesia: halfway there. The Lancet Global Health, 6(6), e604–e606. https://doi.org/10.1016/S2214-109X(18)30198-0
  19. Uzochukwu, B. S. C., Onwujekwe, E., Ezuma, N. N., Ezeoke, O. P., Ajuba, M. O., & Sibeudu, F. T. (2011). Improving rational treatment of malaria: Perceptions and influence of RDTs on prescribing behaviour of health workers in Southeast Nigeria. PLoS ONE, 6(1), 1–7. https://doi.org/10.1371/journal.pone.0014627
  20. World Health Organization, & WHO. (2020). World Malaria Report: 20 years of global progress and challenges. In World Health Organization. https://www.who.int/publications/i/item/9789240015791
  21. Zurovac, D., Rowe, A. K., Ochola, S. A., Noor, A. M., Midia, B., English, M., & Snow, R. W. (2004). Predictors of the quality of health worker treatment practices for uncomplicated malaria at government health facilities in Kenya. International Journal of Epidemiology, 33(5), 1080–1091. https://doi.org/10.1093/ije/dyh253