Main Article Content
Abstract
Capsule shells are generally made from gelatin. The gelatin that is spread in the world is commonly derived from pigs. This animal is forbidden to be consumed by Muslims. This issue is due to the halal aspect. Sago starch and sodium alginate are halal materials that are capable of gelatinizing. This property made it able to be molded as a capsule. This research aims to determine the formula of sago and sodium alginate as a capsule and the evaluation. Three formulas were made with the ratio of sago and sodium alginate 100%: 0% (formula 1), 50%: 50% (formula 2), and 0%: 100% (formula 3). The capsule was manually molded using a food-grade stainless steel capsule mold. The size of the capsule, weight uniformity, swelling, and disintegration time were determined for a physical evaluation. SLD was used to determine the best formula, and the validation was done using One-sample T-test. The evaluations of the capsule shell were found ranged as follows: the size specifications were 21-22 mm, the body diameter was 6.1-7.2 mm, the cap diameter was 13.6-13.8 mm, weight uniformity was 0.10-0.26 gram, the swelling test was 433-1583%, and the disintegration time was 10.20-14.43 minutes. The best formula based on the SLD of the experiment was formula 3, which are two parameters that met the requirements, i.e., swelling and disintegration time. The sago and sodium alginate were crosslinked, and the capsule was made. However, the performance dislike of gelatin capsules. Continued research shall be done to find the optimum formula and its characteristics for alternative material on halal capsules.
Keywords
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
References
- Adicandra, R. M., & Estiasih, T. (2016). Beras Analog Dari Ubi Kelapa Putih (Discorea alata L.): Kajian Pustaka. Jurnal Pangan Dan Agroindustri, 4(1), 383–390. https://jpa.ub.ac.id/index.php/jpa/article/view/340
- Agustin, Y. E., & Padmawijaya, K. S. (2016). Sintesis Bioplastik Dari Kitosan-Pati Kulit Pisang Kepok Dengan Penambahan Zat Aditif. Jurnal Teknik Kimia, 10(2), 43–51. https://doi.org/10.33005/JURNAL_TEKKIM.V10I2.537
- Bolton, S., & Bon, C. (2003). Pharmaceutical Statistics : Practical and Clinical Applications, Revised and Expanded. Pharmaceutical Statistics. https://doi.org/10.1201/9780203912799
- Breger, J. C., Fisher, B., Samy, R., Pollack, S., Wang, N. S., & Isayeva, I. (2015). Synthesis of “click” alginate hydrogel capsules and comparison of their stability, water swelling, and diffusion properties with that of Ca+2 crosslinked alginate capsules. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 103(5), 1120–1132. https://doi.org/10.1002/JBM.B.33282
- Ciptaningrat, L. (2020). Sagu dan Krisis Reproduksi Sosial Orang Kaiso. Wacana: Jurnal Transformasi Sosial, 38, 103–132.
- Derkach, S. R., Voron’ko, N. G., Sokolan, N. I., Kolotova, D. S., & Kuchina, Y. A. (2019). Interactions between gelatin and sodium alginate: UV and FTIR studies. Https://Doi.Org/Journal of Dispersion Science and Technology, 41(5), 690–698. https://doi.org/10.1080/01932691.2019.1611437
- Endriani, B., Endriani, B., Setyawati, D., & Nurhaida, . (2019). Kualitas Papan Partikel Ampas Sagu Berdasarkan Kadar Perekat Asam Sitrat. JURNAL HUTAN LESTARI, 7(2), 884–892. https://doi.org/10.26418/jhl.v7i2.34557
- Faridah, H. D., & Susanti, T. (2018). Polisakarida Sebagai Material Pengganti Gelatin Pada Halal Drug Delivery System Polysaccharide As Gelatin Subtitute Material In Halal Drug Delivery System. Journal of Halal Product and Research, 01(02).
- Herawati, H., Penelitian, B. B., Pengembangan, D., Pertanian, P., Tentara, J., No, P., & -Bogor, C. (2018). The Hydrocolloids Potential As Additive Materials To The Qualified Food and Non-Food Products. Jurnal Litbang Pertanian, 37(Juni), 17–25. https://doi.org/10.21082/jp3.v37n1.2018.p17-25
- Hijriawati, M., & Febrina, E. (2016). Review : Edible Film Antimikroba. Farmaka, 14(1), 8–16. https://doi.org/10.24198/JF.V14I1.10778
- Hu, W., Wang, Z., Xiao, Y., Zhang, S., & Wang, J. (2019). Advances in crosslinking strategies of biomedical hydrogels. Biomaterials Science, 7(3), 843–855. https://doi.org/10.1039/C8BM01246F
- Ihsan, H., Dewa Gede Putra Prabawa, I., Harsono, D., Nintasari, R., Apriani, R., Bayu Nurcahyo Balai Riset dan Standardisasi Industri Banjarbaru Jalan Panglima Batur Barat No, A., & Selatan, K. (2019). Pengujian sifat fisik dan cemaran mikrobapada cangkang kapsulpati sagu rumbia (Metroxylon saguRottb) dan karagenan. Jurnal Riset Industri Hasil Hutan. https://doi.org/10.24111/jrihh.v11i1.4802
- Ihsan, H., Khairiah, N., Balai Riset dan Standardisasi Industri Banjarbaru Jl Panglima Batur Barat No, R., & Selatan, K. (2018). Karakteristik Sifat Fisik dan Kimia Edible Film Pati Sagu Rumbia (Metroxylon sagu Rottb) untuk Bahan Baku Cangkang Kapsul (Characteristics of Physical and Chemical Properties of Edible Film of Rumbia Sago Starch for Capsule Shell Material). Jurnal Riset Industri Hasil Hutan, 10(2), 55–62. https://doi.org/10.24111/JRIHH.V10I2.3972
- Kemenkes RI. (2014). Farmakope Indonesia Edisi V. Kementrian Kesehatan Republik Indonesia.
- Kraemer, Chmura, H., & Blasey, C. (2015). How many subjects?: Statistical power analysis in research. SAGE Publications.
- Maciej Serda, Becker, F. G., Cleary, M., Team, R. M., Holtermann, H., The, D., Agenda, N., Science, P., Sk, S. K., Hinnebusch, R., Hinnebusch A, R., Rabinovich, I., Olmert, Y., Uld, D. Q. G. L. Q., Ri, W. K. H. U., Lq, V., Frxqwu, W. K. H., Zklfk, E., Edvhg, L. V, … فاطمی, ح. (2018). Karakteristik Es Krim Dengan Penambahan Alginat Sebagai Penstabil. Jurnal Pengolahan Dan Bioteknologi Hasil Perikanan, 6(3), 36–42. https://doi.org/10.2/JQUERY.MIN.JS
- Maila, L., Eka Maya, S., & Een, H. (2019). Gizi Kesehatan Pada Masa Reproduksi (Yogyakarta). Deepublish.
- Nugrahanto, A. D., Kurniawati, A., & Erwanto, Y. (2021). Karakteristik fisis bioplastik yang dibuat dari kombinasi pati tapioka dan kasein susu apkir. Majalah Kulit, Karet, Dan Plastik, 37(2), 103–114. https://doi.org/10.20543/MKKP.V37I2.7422
- Oktaviani, I. R., Perdana, F., & Yus Nasution, A. (2017). Perbandingan Sifat Gelatin Yang Berasal Dari Kulit Ikan Patin (Pangasius Hypophthalmus) Dan Gelatin Yang Berasal Dari Kulit Ikan Komersil. JOPS (Journal Of Pharmacy and Science), 1(1), 1–8. https://doi.org/10.36341/JOPS.V1I1.368
- Polnaya, F. J., Ega, L., & Wattimena, D. (2016). Karakteristik Edible Film Pati Sagu Alami dan Pati Sagu Fosfat dengan Penambahan Gliserol. AgriTECH, 36(3), 247–252. https://doi.org/10.22146/AGRITECH.16661
- Rizki, A. D., Arpi, N., & Zakaria, F. (2021). Peningkatan Skala Laboratorium ke Pilot Plant (Scale Up) Produksi Gelatin Berbahan Dasar Limbah Kulit dan Sisik Ikan Tuna (Thunnus Sp.). Jurnal Ilmiah Mahasiswa Pertanian, 6(4), 447–451. https://doi.org/10.17969/JIMFP.V6I4.18318
- Simó, G., Fernández‐Fernández, E., Vila‐Crespo, J., Ruipérez, V., & Rodríguez‐Nogales, J. M. (2017). Research progress in coating techniques of alginate gel polymer for cell encapsulation. Carbohydrate Polymers, 170, 1–14. https://doi.org/10.1016/J.CARBPOL.2017.04.013
- Somo, S. I., Langert, K., Yang, C. Y., Vaicik, M. K., Ibarra, V., Appel, A. A., Akar, B., Cheng, M. H., & Brey, E. M. (2018). Synthesis and evaluation of dual crosslinked alginate microbeads. Acta Biomaterialia, 65, 53–65. https://doi.org/10.1016/J.ACTBIO.2017.10.046
- Suparman, A., Herawati, D., & Fitratul, Z. (2019). Karakterisasi Dan Formulasi Cangkang Kapsul Dari Tepung Pektin Kulit Buah Cokelat (Theobroma Cacao L). Jurnal Ilmiah Farmasi Farmasyifa, 2(2), 77–83.
- Suptijah, P., Jacoeb, A. M., & Deviyanti, N. (2012). Karakterisasi Dan Bioavailabilitas Nanokalsium Cangkang Udang Vannamei (Litopenaeus Vannamei). Jurnal Akuatika, 3(1). http://journal.unpad.ac.id/akuatika/article/view/481
- Suptijah, P., Suseno, S. H., & Kurniawati, K. (2012). Aplikasi Karagenan Sebagai Cangkang Kapsul Keras Alternatif Pengganti Kapsul Gelatin. Jurnal Pengolahan Hasil Perikanan Indonesia, 15(3), 223–231. https://doi.org/10.17844/JPHPI.V15I3.21434
- Susanti, T., Wafiroh, S., Hendradi, E., & Pudjiastuti, P. (2020). Characterization and release profile of sodium diclofenac halal hard shell capsules made from k-carrageenan and xanthan gum with sorbitol plasticizer. Journal of Halal Product and Research (JHPR), 3(1), 1–8. https://doi.org/10.20473/JHPR.VOL.3-ISSUE.1.1-8
- Szekalska, M., Puciłowska, A., Szymańska, E., Ciosek, P., & Winnicka, K. (2016). Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications. International Journal of Polymer Science, 2016. https://doi.org/10.1155/2016/7697031
- Wulandari, D., Staf, ), Atk, P., Program, Y., Teknologi, S., Kulit, P., Ring, Y. J., & Selatan, R. (2016). Pembuatan Edible Film Berbahan Gelatin Kulit Sapi Split Dengan Penambahan Level Gliserol. Berkala Penelitian Teknologi Kulit, Sepatu, Dan Produk Kulit, 15(1), 1–15. https://doi.org/10.58533/BPTKSPK.V15I1.3
- Zahib, I. R., Md Tahir, P., Talib, M., Mohamad, R., Alias, A. H., & Lee, S. H. (2021). Effects of degree of substitution and irradiation doses on the properties of hydrogel prepared from carboxymethyl-sago starch and polyethylene glycol. Carbohydrate Polymers, 252, 117224. https://doi.org/10.1016/J.CARBPOL.2020.117224
- Zhang, L., Liu, J., Zheng, X., Zhang, A., Zhang, X., & Tang, K. (2019). Pullulan dialdehyde crosslinked gelatin hydrogels with high strength for biomedical applications. Carbohydrate Polymers, 216, 45–53. https://doi.org/10.1016/J.CARBPOL.2019.04.004