Jurnal Farmasi Sains dan Praktis

DEVELOPMENT OF LABRASOL®-BASED SNEDDS FOR ENHANCED DELIVERY OF COMBINATION PROPOLIS, SEA CUCUMBER, AND CENTELLA ASIATICAEXTRACTS

Hannie Fitriani, Yandi Syukri, Muhammad Taher — Tue, 30 Sep 2025 13:26:37 +0000

The therapeutic efficacy of natural extracts such as propolis, sea cucumber or gamat (Stichopus hermanii), and pegagan (Centella asiatica) is supported by their anti-inflammatory, antioxidant, and regenerative properties. However, their pharmaceutical application is limited due to poor solubility and low bioavailability. This study aimed to develop and characterize a Self-Nanoemulsifying Drug Delivery System (SNEDDS) using Labrasol to enhance the delivery and stability of a combination of these three extracts, that exhibit synergistic effects as tissue regeneration, antimicrobial, anti-inflammatory, and antioxidant properties. SNEDDS formulations were prepared by a high energy method with Labrasol, Tween 80, and propylene glycol. The formulations were evaluated for droplet size, polydispersity index (PDI), zeta potential, and thermodynamic stability test. The optimized SNEDDS exhibited nano-sized droplets (151.13 nm ± 17.26) with low PDI (0.39 ± 0.01) and zeta potential (-50.30 ± 1.04) within the stable range, indicating a uniform, physically stable nanoemulsion, and passed the thermodynamic stability test. In conclusion, the optimized SNEDDS formulation demonstrated nano-sized droplets with low PDI and stable zeta potential, indicating good physical stability.

PHYSICOCHEMICAL CHARACTERISTICS AND PHARMACOLOGICAL ACTIVITY OF SACHA INCHI SEED OIL (Plukenetia volubilis L.): A LITERATURE REVIEW

Tue, 30 Sep 2025 15:03:52 +0000

Sacha inchi (Plukenetia volubilis L.) of the family Euphorbiaceae is native to Peruvian in the Amazon forest. SaIn seeds are known to contain a significant fatty acid such as linolenic acid (Omega-3), linoleic acid (Omega-6), and oleic acid (Omega-9). Several studies have shown the benefits of Sacha inchi (SaIn) for various pharmacological activities based on its compound content. The aim of this review article is to provide information about pharmacological activities and describe the physicochemical characteristics of SaIn seed oil. The method used to make this article review is a literature study gathered from national and international journals published in the last ten years through Google Scholar, NCBI-Pubmed, and Crossref with search keys in the form "Plukenetia volubilis L.", "Sacha inchi", "pharmacological activity of Sacha inchi", "physicochemical characteristics of Sacha inchi". Based on the literature review, it was found that the physicochemical characteristics of SaIn seed oil with the observed parameters of peroxide value, iodine number, saponification number and acid number showed different values depending on the extraction method used. SaIn has pharmacological activities as antioxidant, anticancer, antidiabetic, antiobesity, anticonvulsant, anti-aging, antihyperlipidemia, antibacterial and potential for alzheimer therapy.

EVALUATION OF PROPHYLACTIC ANTIBIOTIC USE IN SURGICAL PATIENTS USING THE GYSSENS METHOD AT A PRIVATE HOSPITAL IN YOGYAKARTA

Septania Dini Arviani, Imaniar Noor Faridah, Fadli Robbi Amsriza — Tue, 30 Sep 2025 15:26:07 +0000

Prophylactic antibiotics are used before, during, and up to 24 hours after surgery, and can be administered to patients 30-60 minutes before surgery, must adhere to the principle of “Right Antibiotics”. This study aims to assess the application of prophylactic antibiotics in surgical patients in a private hospital in Yogyakarta to promote rational antibiotic use. This study is quantitative and non-experimental. Data were collected prospectively over a period of 30 days from August 4 to September 4, 2024. The study sample consisted of all surgical patients who received prophylactic antibiotics. Prophylactic antibiotic data were analyzed using the Gyssens method. Out of the data collected, 110 patients received preventive antibiotics, and 97 of these patients met the inclusion criteria. Patient characteristics predominantly included a 46% incidence of cesarean sections. Prophylaxis employed three antibiotics, viz. ceftriaxone in 78 patients (79.38%), cefazolin in 19 patients (19.59%), and cefotaxime in 1 patient (1.03%). The assessment utilizing the Gyssens approach revealed that 31 patients were classified into category V (no indication), 49 patients into category IVA (more effective antibiotics available), and one patient into category I (not suitable during prophylaxis). Sixteen patients in category 0 were included in the reasonable antibiotic regimen. This study states that most antibiotics are not in accordance with the Guidelines for Antibiotic Use established by the Ministry of Health of the Republic of Indonesia in 2021.